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A3QA17

- FTHS_SHELP

UniProt

A3QA17 - FTHS_SHELP

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Shew_0443
Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-461-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Shew_0443
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000300537Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323850.Shew_0443.

Structurei

3D structure databases

ProteinModelPortaliA3QA17.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3QA17-1 [UniParc]FASTAAdd to Basket

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MLTDIEISRQ ASLQPIESIA TAFGILPHEL SPYGRTKAKV DLAITNRIKD    50
NKHGKLVIVT AVTPTPFGEG KTVTSIGLTQ GLQAIGKKSC ACIRQPSMGP 100
VFGIKGGAAG GGLAQVVPME DLNLHLTGDI HAVTSAHNLA AAAIDARLYH 150
EQRLGCEAFR EQSGLAPLDI DPEKILWRRV VDQNERSLRT ITVGLGEVNG 200
PVHQGGFDIS AASELMAILA LSRDLKDLRA RIGRIVLAQN KQGDYISAED 250
LGVAGAMTAI MSQAISPTLM QTLSGAPCLI HAGPFANIAH GNSSIIADDI 300
ALRLADIVVT EGGFGSDMGF EKFCNIKTRQ SGNAPDAAVL VVTVKALKSH 350
NPDAGSEMDK LAAGYANLSW HISNVAKYGL PLVVAINRFA EDTQEELEWL 400
KARVLQEGVF ACEVCEAFTQ GAEGAMALAR AVVRATEQPS QFRYLYETKQ 450
SIEAKLLTIA EAGYGANGIS LSDTAKAQLA QLQRQGFDKL ALCIAKTPMS 500
VSHDPKLKGA PQGFELPIAE LKLNAGAGFI TALVGKVMTM PGLGIRPGYL 550
NIDIDERGEI TGLA 564
Length:564
Mass (Da):59,785
Last modified:April 17, 2007 - v1
Checksum:i4D1C5024D1BF473A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO22315.1.
RefSeqiYP_001092574.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO22315; ABO22315; Shew_0443.
GeneIDi4920697.
KEGGislo:Shew_0443.
PATRICi23512653. VBISheLoi132094_0449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO22315.1 .
RefSeqi YP_001092574.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QA17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_0443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO22315 ; ABO22315 ; Shew_0443 .
GeneIDi 4920697.
KEGGi slo:Shew_0443.
PATRICi 23512653. VBISheLoi132094_0449.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SLOI323850:GHQJ-461-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiFTHS_SHELP
AccessioniPrimary (citable) accession number: A3QA17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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