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A3QA17

- FTHS_SHELP

UniProt

A3QA17 - FTHS_SHELP

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSLOI323850:GHQJ-461-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Shew_0443
    OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
    Taxonomic identifieri323850 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001558: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Formate--tetrahydrofolate ligasePRO_0000300537Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323850.Shew_0443.

    Structurei

    3D structure databases

    ProteinModelPortaliA3QA17.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3QA17-1 [UniParc]FASTAAdd to Basket

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    MLTDIEISRQ ASLQPIESIA TAFGILPHEL SPYGRTKAKV DLAITNRIKD    50
    NKHGKLVIVT AVTPTPFGEG KTVTSIGLTQ GLQAIGKKSC ACIRQPSMGP 100
    VFGIKGGAAG GGLAQVVPME DLNLHLTGDI HAVTSAHNLA AAAIDARLYH 150
    EQRLGCEAFR EQSGLAPLDI DPEKILWRRV VDQNERSLRT ITVGLGEVNG 200
    PVHQGGFDIS AASELMAILA LSRDLKDLRA RIGRIVLAQN KQGDYISAED 250
    LGVAGAMTAI MSQAISPTLM QTLSGAPCLI HAGPFANIAH GNSSIIADDI 300
    ALRLADIVVT EGGFGSDMGF EKFCNIKTRQ SGNAPDAAVL VVTVKALKSH 350
    NPDAGSEMDK LAAGYANLSW HISNVAKYGL PLVVAINRFA EDTQEELEWL 400
    KARVLQEGVF ACEVCEAFTQ GAEGAMALAR AVVRATEQPS QFRYLYETKQ 450
    SIEAKLLTIA EAGYGANGIS LSDTAKAQLA QLQRQGFDKL ALCIAKTPMS 500
    VSHDPKLKGA PQGFELPIAE LKLNAGAGFI TALVGKVMTM PGLGIRPGYL 550
    NIDIDERGEI TGLA 564
    Length:564
    Mass (Da):59,785
    Last modified:April 17, 2007 - v1
    Checksum:i4D1C5024D1BF473A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO22315.1.
    RefSeqiYP_001092574.1. NC_009092.1.

    Genome annotation databases

    EnsemblBacteriaiABO22315; ABO22315; Shew_0443.
    GeneIDi4920697.
    KEGGislo:Shew_0443.
    PATRICi23512653. VBISheLoi132094_0449.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO22315.1 .
    RefSeqi YP_001092574.1. NC_009092.1.

    3D structure databases

    ProteinModelPortali A3QA17.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323850.Shew_0443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO22315 ; ABO22315 ; Shew_0443 .
    GeneIDi 4920697.
    KEGGi slo:Shew_0443.
    PATRICi 23512653. VBISheLoi132094_0449.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SLOI323850:GHQJ-461-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1088 / PV-4.

    Entry informationi

    Entry nameiFTHS_SHELP
    AccessioniPrimary (citable) accession number: A3QA17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3