ID   A3Q9P3_SHELP            Unreviewed;       806 AA.
AC   A3Q9P3;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE   AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE   AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN   OrderedLocusNames=Shew_0319 {ECO:0000313|EMBL:ABO22191.1};
OS   Shewanella loihica (strain ATCC BAA-1088 / PV-4).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=323850 {ECO:0000313|EMBL:ABO22191.1, ECO:0000313|Proteomes:UP000001558};
RN   [1] {ECO:0000313|EMBL:ABO22191.1, ECO:0000313|Proteomes:UP000001558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1088 / PV-4 {ECO:0000313|Proteomes:UP000001558};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Serres G.,
RA   Fredrickson J., Tiedje J., Richardson P.;
RT   "Complete sequence of Shewanella loihica PV-4.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; CP000606; ABO22191.1; -; Genomic_DNA.
DR   RefSeq; WP_011864125.1; NC_009092.1.
DR   AlphaFoldDB; A3Q9P3; -.
DR   STRING; 323850.Shew_0319; -.
DR   KEGG; slo:Shew_0319; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000001558; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   InterPro; IPR043519; NT_sf.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001558}.
FT   DOMAIN          6..203
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   806 AA;  92924 MW;  E9B5ADFB354C796B CRC64;
     MKEQEHFIAT AERLNKVRLA RALAMLTPLQ RHLMQLIPVL FHYHRSDFPG YNGPMTPSGV
     FEYFPSDDAL EACRTLGLSE PQVIHQQQSA LYGVYTMGST ASFGQNPKSD IDVWLVYDPT
     LADDEIASLQ DKSQLLTAWF GQHDLEVNIY LVHPKQFISS SRDGVVQTAS LGCENSGSVQ
     HWLLLEEFYR SQICLGGKRV AWWPGAEAIE SHLFLGDVSN LPASEYFGAS LWQLYKGLDK
     PHKALLKVML LEAYASDYPN SNLVTTQVWQ RTLAGDFSAF NDAYFLLYQS IEHYLEYKND
     KRRLEIVRRC FYLKCGIRLT VAEHPKDWRY YKLQSLVTRW GWSDNLLRTL DQCASWHCGQ
     LQWFNEQLNE LMLGCYQTLL QFASANKLSD SLKISELGLL TRKLHTYFSE DDKQIISLNR
     LWTRSVAEAH LTVIYSHNTK EYYLYRCTPE SKNFMGNRAV FHSHSKAKLL IWASLNGVST
     AQTQWYAYGE GKGQDKALTK AAKRLPTIMT ERRWRASKLD LCQPWHFRQL LFLINFNRDE
     TQLWRGQEII FDYMNANIFS MGRHHRNMVQ SLDVICQNSW GEWHCHHFEG NEAILDALVY
     ITPGMQRAPQ QVKVDVVSCS SRLSTQIERS ISQLVHRANR MCTKAKTSST MVHPLQVGGI
     KYGLFFNSKG MVYQDLSEST AFYQRLSKQR MLELPRPDLG NEPFSKIPEV IQDFAAIGAI
     QYFLRPGKEG IDVFVLDEKN ELNHYVQPGN NLEELVSQVS HHHAFADSYL DNERFNLPQF
     FRLVRVDGRL QAQPFGVNVD EAAIEF
//