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A3Q8Q1

- SYL_MYCSJ

UniProt

A3Q8Q1 - SYL_MYCSJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium sp. (strain JLS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei725 – 7251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP164757:GHV3-5818-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mjls_5765
OrganismiMycobacterium sp. (strain JLS)
Taxonomic identifieri164757 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000002152: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligasePRO_0000334776Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164757.Mjls_5765.

Structurei

3D structure databases

ProteinModelPortaliA3Q8Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi72 – 8312"HIGH" regionAdd
BLAST
Motifi722 – 7265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3Q8Q1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTETPTAQPD RAADADTPQH RYTAELAGQI EGAWQQTWAV EGTFNVPNPV
60 70 80 90 100
GELAPPDGTV PADKMFVQDM FPYPSGEGLH VGHPLGYIAT DVYARYYRMT
110 120 130 140 150
GRNVLHALGF DAFGLPAEQY AVQTGTHPRT RTEANIVNFR RQLGRLGLGH
160 170 180 190 200
DTRRSFSTTD VDFYTWTQWI FLQIYNAWFD RDANRARPIA ELIGEFESGV
210 220 230 240 250
RTLDDGRPWS ELSAGERADV VDSYRLVYRA DSMVNWCPGL GTVLANEEVT
260 270 280 290 300
ADGRSDRGNF PVFRKRLRQW MMRITAYSDR LLEDLEVLDW PDKVKTMQRN
310 320 330 340 350
WIGRSTGASV QFGTDAGDIE VFTTRPDTLF GATYLVLAPE HPLVEQLAAE
360 370 380 390 400
QWPDDVDGRW TFGATTPREA VAAYRASIAA KSDLERQENK TKTGAFLGAY
410 420 430 440 450
ATNPANGQQV PIFIADYVLI GYGTGAIMAV PGHDQRDWEF AHEFGLPVVE
460 470 480 490 500
VISGGDISEA AYAGDGLLVN SDYLDGLDVA AAKAAITDRL VADGRGRARV
510 520 530 540 550
EYKLRDWLFA RQRYWGEPFP IVYDSDGRPH PLPESALPVE LPDVPDYSPV
560 570 580 590 600
LFDPDDADSE PNPPLNKATD WVHVELDLGD GLQTYTRDTN VMPQWAGSSW
610 620 630 640 650
YELRYTDPLN KEALCAKENE AYWMGPRPAE HGPDDPGGVD LYVGGVEHAV
660 670 680 690 700
LHLLYSRFWH KVLYDLGHVS SREPYRRLVN QGYIQAFAYT DSRGSYVPAA
710 720 730 740 750
EVVERDGKFW FEGAEVFQEF GKIGKSLKNS VSPDEICDNY GADTLRVYEM
760 770 780 790 800
SMGPLEASRP WATKDVVGAH RFLQRVWRLV VDEQSGAVRV ANHEALDTDT
810 820 830 840 850
LRALHRTVAG VSEDYAALRN NTAAAKLIEY TNHLTKEGVT ARAAIEPLVL
860 870 880 890 900
MVAPLAPHLA EELWRRLGHD TSLAHGPFPV ADPQYLVTDT VEYPVQVNGK
910 920 930 940 950
VRSRITVDAD AGKDTLEAAA LADEKVQAFL NGATPKKVIV VPGRLVNLVV
Length:950
Mass (Da):105,623
Last modified:May 20, 2008 - v2
Checksum:iDCC3614026DCFC7A
GO

Sequence cautioni

The sequence ABO01529.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABO01529.1. Different initiation.
RefSeqiWP_011857604.1. NC_009077.1.
YP_001074019.1. NC_009077.1.

Genome annotation databases

EnsemblBacteriaiABO01529; ABO01529; Mjls_5765.
GeneIDi4881462.
KEGGimjl:Mjls_5765.
PATRICi18097843. VBIMycSp51234_5820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABO01529.1 . Different initiation.
RefSeqi WP_011857604.1. NC_009077.1.
YP_001074019.1. NC_009077.1.

3D structure databases

ProteinModelPortali A3Q8Q1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164757.Mjls_5765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO01529 ; ABO01529 ; Mjls_5765 .
GeneIDi 4881462.
KEGGi mjl:Mjls_5765.
PATRICi 18097843. VBIMycSp51234_5820.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MSP164757:GHV3-5818-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JLS.

Entry informationi

Entry nameiSYL_MYCSJ
AccessioniPrimary (citable) accession number: A3Q8Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3