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A3Q733 (A3Q733_MYCSJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123
Gene names
Name:acsA HAMAP MF_01123
Ordered Locus Names:Mjls_5196
OrganismMycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]
Taxonomic identifier164757 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5351 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6291N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
A3Q733 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 940DF376B0D368BF

FASTA66673,118
        10         20         30         40         50         60 
MCSSRRVTTL TPMSDVHTEV PSSYPPPAEF AEQANAKAEM YREAEEDRLA FWAKQAERLS 

        70         80         90        100        110        120 
WDTPFTEVLD WSDAPFAKWF VGGKINVAYN CVDRHVEAGN GDRVAIHWEG EPVGDSRSLT 

       130        140        150        160        170        180 
YAELKDEVCK AANALTDLGL TAGDRAAIYM PMVPEAIVAM LACARLGVLH SVVFAGFSAS 

       190        200        210        220        230        240 
ALKARIEDAE AKLVITTDGQ YRRGKAASLK DAVDEAVDGQ PSIEHVLVVR RTGIDVKWTD 

       250        260        270        280        290        300 
GRDLWWHETV DGASTEHTPE AFDSEHPLFL LYTSGTTGKP KGIVHTTGGY LVQSSYTHHN 

       310        320        330        340        350        360 
VFDVKPDTDV YWCTADIGWV TGHTYITYGP LSNGVTQVVY EGTPTSPSEH RHFEVIEKYG 

       370        380        390        400        410        420 
VTIYYTAPTL VRTFMKLGRA VPDAHDLSSL RLLGSVGEPI NPEAWRWYRN VFGDNNIPVV 

       430        440        450        460        470        480 
DTWWQTETGA IMISPLPGVT AAKPGSAMTP LPGISAKIVD DDGNQLPPGS DHGEQANGYL 

       490        500        510        520        530        540 
VLDQPWPAML RGIWGDPQRF KETYWSRFAE QGWYFAGDGA RYDADGNIWV LGRIDDVMNI 

       550        560        570        580        590        600 
SGHRISTAEV ESALVGHAHV AEAAVVGATD DHTGQAICAF VILESSAADK PHEHMVEELR 

       610        620        630        640        650        660 
AEVAKEISPI ARPREIHVVP ELPKTRSGKI MRRLLRDVAE GRELGDTSTL VDPGVFEAIR 


ASKAEV

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References

[1]"Complete sequence of Mycobacterium sp. JLS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JLS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000580 Genomic DNA. Translation: ABO00961.1.
RefSeqYP_001073451.1. NC_009077.1.

3D structure databases

ProteinModelPortalA3Q733.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3Q733.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000047829; EBMYCP00000046110; EBMYCG00000047824.
GeneID4880894.
GenomeReviewsGene locus Mjls_5196 in contig CP000580_GR.
KEGGmjl:Mjls_5196.
PATRIC18096651. VBIMycSp51234_5231.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
GeneTreeEBGT00050000015141.
HOGENOMHBG547964.
OMAVISVSGH.
PhylomeDBA3Q733.
ProtClustDBPRK00174.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA3Q733_MYCSJ
AccessionPrimary (citable) accession number: A3Q733
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info