A3Q6A9 (A3Q6A9_MYCSJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370

Gene names

Ordered Locus Names:

Mjls_4921

Organism

Mycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]

Taxonomic identifier

164757 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733
Subcellular location	Cytoplasm By similarity SAAS SAAS004733.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS004733
Cellular component	Cytoplasm SAAS SAAS004733
Ligand	ATP-binding SAAS SAAS004733 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 SAAS SAAS004733 EMBL ABO00687.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3Q6A9 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 349DC7417ABF62B0	FASTA	357	37,817
	10 20 30 40 50 60 MTERAEQHGI SYASAGVDIE AGDRAVELFK PLAAKATRPE VRGGLGGFAG LFALRGGYRE 70 80 90 100 110 120 PVLASSTDGV GTKLAVAQAM DKHDTVGLDL VAMVVDDLVV CGAEPLFLQD YIAVGRTVPE 130 140 150 160 170 180 RVSQLVAGIA EGCVIAGCAL LGGETAEHPG LMAPDHYDIS ATGIGIVEAD DVLGPDRVRP 190 200 210 220 230 240 GDVIIAMGSS GLHSNGYSLA RKVLLEIDRM NLAGHVEEFG RTLGEELLEP TRIYAKDCLA 250 260 270 280 290 300 LAAETQVRTF CHVTGGGLAG NLERVVPNGL MAELDRGTWT PAPVFQMIAQ RGRIERTEME 310 320 330 340 350 KTFNMGIGMV AVVAPEDTDR ALAILTARHI DCWTLGTVKK GGKDEPRALL VGQHPRF

References

[1]

"Complete sequence of Mycobacterium sp. JLS." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JLS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000580 Genomic DNA. Translation: ABO00687.1.
RefSeq	YP_001073177.1. NC_009077.1.
3D structure databases
ProteinModelPortal	A3Q6A9.
ModBase	Search...
Protein-protein interaction databases
STRING	A3Q6A9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000051165; EBMYCP00000049446; EBMYCG00000051160.
GeneID	4880620.
GenomeReviews	Gene locus Mjls_4921 in contig CP000580_GR.
KEGG	mjl:Mjls_4921.
PATRIC	18096095. VBIMycSp51234_4955.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
GeneTree	EBGT00050000016383.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3Q6A9_MYCSJ

Accession

Primary (citable) accession number: A3Q6A9

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)