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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Mycobacterium sp. (strain JLS)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei178DesacetylmycothiolUniRule annotation1
Binding sitei219DesacetylmycothiolUniRule annotation1
Binding sitei227DesacetylmycothiolUniRule annotation1
Binding sitei269Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Mjls_4907
OrganismiMycobacterium sp. (strain JLS)
Taxonomic identifieri164757 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002761 – 300Mycothiol acetyltransferaseAdd BLAST300

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi164757.Mjls_4907.

Structurei

3D structure databases

ProteinModelPortaliA3Q695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 140N-acetyltransferase 1UniRule annotationAdd BLAST137
Domaini151 – 300N-acetyltransferase 2UniRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 81Acetyl-CoA binding 1UniRule annotation3
Regioni231 – 233Acetyl-CoA binding 2UniRule annotation3
Regioni274 – 279Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiGVRHVIS.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3Q695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIDWRSAL TDDEQGSIRD IVAAATRHDG VAPVGDQVLR ELPADRTRHL
60 70 80 90 100
VAVDPDAGAV VGYLNLAPAS DTAPPMAELV VHPDFRRRGT GAAMARAGLA
110 120 130 140 150
EGGTHARIWA HGNLEAARAT ARTLGLQVVR ELLQMRRPLT DLPPVTVADG
160 170 180 190 200
VRLATYSGPG DDPELLRVNN SAFAWHPEQG GWTDADIAER RAEAWFDPAG
210 220 230 240 250
LFMAFDDASG KLLGFHWTKV HGPDLGEVYV VGVDPAAQGR GLGATLTLTG
260 270 280 290 300
LHHLAERLSN SPQPTVMLYV EADNGAAVKT YRRLGFDVSS VDAAYAAVAD
Length:300
Mass (Da):31,948
Last modified:April 3, 2007 - v1
Checksum:i5154C3EE561AC6C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABO00673.1.
RefSeqiWP_011857052.1. NC_009077.1.

Genome annotation databases

EnsemblBacteriaiABO00673; ABO00673; Mjls_4907.
KEGGimjl:Mjls_4907.
PATRICi18096067. VBIMycSp51234_4941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABO00673.1.
RefSeqiWP_011857052.1. NC_009077.1.

3D structure databases

ProteinModelPortaliA3Q695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi164757.Mjls_4907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO00673; ABO00673; Mjls_4907.
KEGGimjl:Mjls_4907.
PATRICi18096067. VBIMycSp51234_4941.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiGVRHVIS.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_MYCSJ
AccessioniPrimary (citable) accession number: A3Q695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.