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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Mycobacterium sp. (strain JLS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei178DesacetylmycothiolUniRule annotation1
Binding sitei219DesacetylmycothiolUniRule annotation1
Binding sitei227DesacetylmycothiolUniRule annotation1
Binding sitei269Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciMSP164757:G1G8C-4957-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Mjls_4907
OrganismiMycobacterium sp. (strain JLS)
Taxonomic identifieri164757 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002761 – 300Mycothiol acetyltransferaseAdd BLAST300

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA3Q695
SMRiA3Q695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 140N-acetyltransferase 1UniRule annotationAdd BLAST137
Domaini151 – 300N-acetyltransferase 2UniRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 81Acetyl-CoA binding 1UniRule annotation3
Regioni231 – 233Acetyl-CoA binding 2UniRule annotation3
Regioni274 – 279Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV Bacteria
COG0456 LUCA
HOGENOMiHOG000248937
KOiK15520
OMAiAEPWFDP
OrthoDBiPOG091H09IL

Family and domain databases

HAMAPiMF_01698 MshD, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR017813 Mycothiol_AcTrfase
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PIRSFiPIRSF021524 MSH_acetyltransferase, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR03448 mycothiol_MshD, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 2 hits

Sequencei

Sequence statusi: Complete.

A3Q695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIDWRSAL TDDEQGSIRD IVAAATRHDG VAPVGDQVLR ELPADRTRHL
60 70 80 90 100
VAVDPDAGAV VGYLNLAPAS DTAPPMAELV VHPDFRRRGT GAAMARAGLA
110 120 130 140 150
EGGTHARIWA HGNLEAARAT ARTLGLQVVR ELLQMRRPLT DLPPVTVADG
160 170 180 190 200
VRLATYSGPG DDPELLRVNN SAFAWHPEQG GWTDADIAER RAEAWFDPAG
210 220 230 240 250
LFMAFDDASG KLLGFHWTKV HGPDLGEVYV VGVDPAAQGR GLGATLTLTG
260 270 280 290 300
LHHLAERLSN SPQPTVMLYV EADNGAAVKT YRRLGFDVSS VDAAYAAVAD
Length:300
Mass (Da):31,948
Last modified:April 3, 2007 - v1
Checksum:i5154C3EE561AC6C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA Translation: ABO00673.1
RefSeqiWP_011857052.1, NC_009077.1

Genome annotation databases

EnsemblBacteriaiABO00673; ABO00673; Mjls_4907
KEGGimjl:Mjls_4907

Similar proteinsi

Entry informationi

Entry nameiMSHD_MYCSJ
AccessioniPrimary (citable) accession number: A3Q695
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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