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A3Q5N7

- PUR9_MYCSJ

UniProt

A3Q5N7 - PUR9_MYCSJ

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Mycobacterium sp. (strain JLS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMSP164757:GHV3-4737-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Mjls_4699
OrganismiMycobacterium sp. (strain JLS)
Taxonomic identifieri164757 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000002152: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Bifunctional purine biosynthesis protein PurHPRO_1000018911Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164757.Mjls_4699.

Structurei

3D structure databases

ProteinModelPortaliA3Q5N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A3Q5N7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGDQGQAGA KRPIRRALIS VYDKSGLIDL ARGLHEAGVD IVSTGSTAKT
60 70 80 90 100
IADKGIPVTP VEFVTGFPEV LDGRVKTLHP HIHAGLLADT RKPEHVEALA
110 120 130 140 150
KLGIAPFDLV VVNLYPFSET VESGASVDEC VEQIDIGGPS MVRAAAKNHP
160 170 180 190 200
SVAVVVEPNG YDGVLAAVRT GGFTLAERKI LASLAFRHTA EYDVAVASWM
210 220 230 240 250
GSTLAPEEPA QKLPAWVGGT WRRAAVLRYG ENPHQQAALY RDATAWPGLA
260 270 280 290 300
QAEQLHGKEM SYNNYTDADA AWRAAFDHEE ICVAIIKHAN PCGIAISSVS
310 320 330 340 350
VADAHRKAHE CDPLSAFGGV IATNSSVSVE MAETVADIFT EVIVAPAYEP
360 370 380 390 400
GAVEILSRKK NIRILLAAQP PTTGTELRPI SGGLLLQQRD ALDADGDDPV
410 420 430 440 450
NWTLATGEPA DPATLANLKF AWRSCRAVKS NAIVVVADGA TVGVGMGQVN
460 470 480 490 500
RVDAARLAVQ RAGDRVRGAI AASDAFFPFP DGLETLTEAG VKAIVHPGGS
510 520
MRDDVVTEAA AKAGISLYLT GARHFAH
Length:527
Mass (Da):55,547
Last modified:April 3, 2007 - v1
Checksum:iBC114925831574C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000580 Genomic DNA. Translation: ABO00465.1.
RefSeqiWP_011856938.1. NC_009077.1.
YP_001072955.1. NC_009077.1.

Genome annotation databases

EnsemblBacteriaiABO00465; ABO00465; Mjls_4699.
GeneIDi4880398.
KEGGimjl:Mjls_4699.
PATRICi18095620. VBIMycSp51234_4723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000580 Genomic DNA. Translation: ABO00465.1 .
RefSeqi WP_011856938.1. NC_009077.1.
YP_001072955.1. NC_009077.1.

3D structure databases

ProteinModelPortali A3Q5N7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164757.Mjls_4699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO00465 ; ABO00465 ; Mjls_4699 .
GeneIDi 4880398.
KEGGi mjl:Mjls_4699.
PATRICi 18095620. VBIMycSp51234_4723.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MSP164757:GHV3-4737-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JLS.

Entry informationi

Entry nameiPUR9_MYCSJ
AccessioniPrimary (citable) accession number: A3Q5N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3