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A3Q5H9 (A3Q5H9_MYCSJ) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Short name=CMK HAMAP-Rule MF_00061
EC=2.7.1.148 HAMAP-Rule MF_00061
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Gene names
Name:ispE HAMAP-Rule MF_00061
Ordered Locus Names:Mjls_4641
OrganismMycobacterium sp. (strain JLS) [Complete proteome] [HAMAP] EMBL ABO00407.1
Taxonomic identifier164757 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061 SAAS SAAS004424

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061 SAAS SAAS004424

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061 SAAS SAAS004424

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily. HAMAP-Rule MF_00061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding108 – 11811ATP By similarity HAMAP-Rule MF_00061

Sites

Active site231 By similarity HAMAP-Rule MF_00061
Active site1501 By similarity HAMAP-Rule MF_00061

Sequences

Sequence LengthMass (Da)Tools
A3Q5H9 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 6847502C9803ED36

FASTA32233,000
        10         20         30         40         50         60 
MRNGNTASEW VPTGSVTVRV PGKVNLFLGV GDLRDDGYHD LTTVFHAVSL LDEVTVSTAD 

        70         80         90        100        110        120 
TLSLDLAGEG AESLPTDRRN LAWKAAELMA EHVGRSPDVA ISIEKSIPVA GGMAGGSADA 

       130        140        150        160        170        180 
AGVLVAMNHL WEIGVPRRDL HAMAAELGSD VPFALHGGTA LGTGRGEELA TVLARSTFHW 

       190        200        210        220        230        240 
VLAFAYKGLS TPKVFRELDR LRATAGAARA EPARLGDPEP MLAALASGDA RQLAPLLGND 

       250        260        270        280        290        300 
LQAAALSLSP DLRRTLRAGL DAGALAAIVS GSGPTCAFLC ASSPQAIDVG ARLAGAGVCR 

       310        320 
TVRVASGPVQ GARVVPAPSP SV

« Hide

References

[1]"Complete sequence of Mycobacterium sp. JLS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JLS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000580 Genomic DNA. Translation: ABO00407.1.
RefSeqYP_001072897.1. NC_009077.1.

3D structure databases

ProteinModelPortalA3Q5H9.
ModBaseSearch...

Protein-protein interaction databases

STRING164757.Mjls_4641.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO00407; ABO00407; Mjls_4641.
GeneID4880340.
KEGGmjl:Mjls_4641.
PATRIC18095500. VBIMycSp51234_4664.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1947.
HOGENOMHOG000019600.
KOK00919.
OMALMGVNEL.
ProtClustDBPRK03188.

Enzyme and pathway databases

BioCycMSP164757:GHV3-4678-MONOMER.
UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA3Q5H9_MYCSJ
AccessionPrimary (citable) accession number: A3Q5H9
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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