A3Q3N5 (KGD_MYCSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate decarboxylase
EC=4.1.1.71

Alternative name(s):
2-oxoglutarate carboxy-lyase
Alpha-ketoglutarate decarboxylase

Gene names

Name:	kgd
Ordered Locus Names:	Mjls_3987

Organism

Mycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]

Taxonomic identifier

164757 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes an oxidative decarboxylation from five-carbon 2-oxoglutarate (alpha-ketoglutarate) to four-carbon succinate semialdehyde By similarity.
Catalytic activity	2-oxoglutarate = succinate semialdehyde + CO2.
Cofactor	Magnesium By similarity. Thiamine pyrophosphate By similarity.
Sequence similarities	Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Domain	Coiled coil
Ligand	Magnesium Thiamine pyrophosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-oxoglutarate decarboxylase activity Inferred from electronic annotation. Source: EC oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1264	1264	2-oxoglutarate decarboxylase		PRO_0000310719
Regions
	Coiled coil	819 – 850	32	Potential

Sequences

	Sequence		Length	Mass (Da)
	A3Q3N5 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: C5068956C2130DAC	FASTA	1,264	139,593
	10 20 30 40 50 60 MSSSPSPFGQ NEWLVEEMYR KFREDPSSVD PSWHEFLVDY NPEPTTDSSA SENGQQTRTA 70 80 90 100 110 120 APKAPPEPAP APAPKSQDSK SQAPKQDSKP QESKPQAKAK PAESKSSTKP ADAKSEKSGK 130 140 150 160 170 180 SGTNGAAKPA AQPADDSDQN QVLRGAAAAV AKNMSASLDV PTATSVRAIP AKLMIDNRVV 190 200 210 220 230 240 INNHLKRTRG GKISFTHLIG YAIVAAVKKF PNMNRHFAEV DGKPNAVTPA HTNLGLAIDL 250 260 270 280 290 300 QGKDGNRQLV VAAIKKADTM RFGQFIAAYE DIVRRARDGK LTAEDFSGVT ISLTNPGTIG 310 320 330 340 350 360 TVHSVPRLMR GQGAIIGVGA MEYPAEFQGA SEERIADLGI GKLITLTSTY DHRIIQGAES 370 380 390 400 410 420 GDFLRTVHQL LLSDDFFDEI FRELGIPYEP VRWRTDNPDS IEDKNARVIE LIAAYRNRGH 430 440 450 460 470 480 LMADIDPLRL DSNRFRSHPD LDVLTHGLTL WDLDREFKVN GFAGAERKKL RDVLAVLRDA 490 500 510 520 530 540 YCRHIGVEYT HILEPEQQQW LQERIEGKHE KPTVAQQKYI LSRLNAAEAF ETFLQTKYVG 550 560 570 580 590 600 QKRFSLEGAE TVIPAMDAVI DQCAEHALDE VVIGMPHRGR LNVLANIVGK PYSQIFSEFE 610 620 630 640 650 660 GNLNPSQAHG SGDVKYHLGS SGTYLQMFGD NDITVSLTAN PSHLEAVDPV MEGLVRAKQD 670 680 690 700 710 720 LLDKGDTEDG YTVVPLMLHG DAAFAGQGVV AETLNLALLR GYRTGGTIHL IVNNQIGFTT 730 740 750 760 770 780 SPAAAKSSEY CTDVAKMIGA PIFHVNGDDP EAAVWVSRLA VDFRQKFKKD VVIDLLCYRR 790 800 810 820 830 840 RGHNEGDDPS MTQPSMYDVI DTKRGVRKSY TEALIGRGDI SMKEAEDALR DYQGQLEQVF 850 860 870 880 890 900 NEVRELEKHE IEPSESVEAD QQIPAKLATA VDKSLLARIG DAHLAVPEGF TVHPRVKPVL 910 920 930 940 950 960 EKRREMAYEG KVDWAFAELL ALGTMISEGK LVRLSGQDTR RGTFTQRHSV VIDRKTGKEF 970 980 990 1000 1010 1020 TPLQLLATDS DGNPTGGKFL VYDSPLSEFA AVGFEYGYSV GNPDAMVLWE AQFGDFINGA 1030 1040 1050 1060 1070 1080 QSIIDEFISS GEAKWGQLSD VVLLLPHGHE GQGPDHTSGR IERFLQLWAE GSMTIALPST 1090 1100 1110 1120 1130 1140 PANYFHLLRR HSLDGIQRPL IVFTPKSMLR NKAAVSDIRD FTEQKFRSVL EEPTYTDGDG 1150 1160 1170 1180 1190 1200 DRNKVTRILL TSGKIYYELV ARKNKESRDD VAIVRIEQLA PLPKRRLAET LDKYPNVDEK 1210 1220 1230 1240 1250 1260 FWVQEEPANQ GAWPTFGLTL PEMLPDHFTG IKRISRRAMS APSSGSSKVH AVEQQEILDE AFAP

References

[1]

"Complete sequence of Mycobacterium sp. JLS." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JLS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000580 Genomic DNA. Translation: ABN99762.1.
RefSeq	YP_001072253.1. NC_009077.1.
3D structure databases
ProteinModelPortal	A3Q3N5.
ModBase	Search...
Protein-protein interaction databases
STRING	A3Q3N5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000047713; EBMYCP00000045994; EBMYCG00000047708.
GeneID	4879696.
GenomeReviews	Gene locus Mjls_3987 in contig CP000580_GR.
KEGG	mjl:Mjls_3987.
PATRIC	18094212. VBIMycSp51234_4021.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
GeneTree	EBGT00050000014858.
HOGENOM	HBG289950.
OMA	EGDEPAF.
PhylomeDB	A3Q3N5.
ProtClustDB	PRK12270.
Enzyme and pathway databases
BioCyc	MSP164757:MJLS_3987-MONOMER.
Family and domain databases
InterPro	IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
KO	K01616.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KGD_MYCSJ

Accession

Primary (citable) accession number: A3Q3N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program