A3PZA2 (PGK_MYCSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	Mjls_2445

Organism

Mycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]

Taxonomic identifier

164757 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145
Subunit structure	Monomer By similarity. HAMAP MF_00145
Subcellular location	Cytoplasm Potential HAMAP MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Phosphoglycerate kinase HAMAP MF_00145		PRO_1000009632
Regions
	Nucleotide binding	363 – 366	4	ATP By similarity
	Region	27 – 29	3	Substrate binding By similarity
	Region	66 – 69	4	Substrate binding By similarity
Sites
	Binding site	43	1	Substrate By similarity
	Binding site	125	1	Substrate By similarity
	Binding site	165	1	Substrate By similarity
	Binding site	215	1	ATP By similarity
	Binding site	303	1	ATP; via carbonyl oxygen By similarity
	Binding site	334	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3PZA2 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 633675F3A253B54D	FASTA	407	42,410
	10 20 30 40 50 60 MAVKTLEDLL NDGDREIAGR GVLVRSDLNV PLDDNGAITD PGRIIASVPT LEALAEAGAK 70 80 90 100 110 120 VIVTAHLGRP KGGPDPKYSL KPVAAALSEK LGRHVQLAGD VVGTDALARA EGLTDGDVLL 130 140 150 160 170 180 LENIRFDPRE TSKDDGERRK LAEALVELVG DDGAFVSDGF GVVHRKQASV YDIATLLPHY 190 200 210 220 230 240 AGTLVAAEVK VLEQLTSSTD RPYAVVLGGS KVSDKLAVIE SLAKKADSLV IGGGMCFTFL 250 260 270 280 290 300 ASQGVSVGKS LVQPEMIDTC RELLDTYGDV IHLPVDIVVA PEFSADAEPE TVAADRIPED 310 320 330 340 350 360 KMGLDIGPES VKRFTNLLSN ARTVFWNGPM GVFEFPAFAA GTKGVAEAII GATAKGAFSV 370 380 390 400 VGGGDSAAAV RQLGLAEDGF SHISTGGGAS LEYLEGKELP GIQVLES

References

[1]

"Complete sequence of Mycobacterium sp. JLS." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JLS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000580 Genomic DNA. Translation: ABN98229.1.
RefSeq	YP_001070720.1. NC_009077.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3PZA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000048591; EBMYCP00000046872; EBMYCG00000048586.
GeneID	4878163.
GenomeReviews	Gene locus Mjls_2445 in contig CP000580_GR.
KEGG	mjl:Mjls_2445.
PATRIC	18091034. VBIMycSp51234_2453.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0126.
GeneTree	EBGT00050000017271.
HOGENOM	HBG453500.
OMA	AKPMAAI.
ProtClustDB	PRK00073.
Enzyme and pathway databases
BioCyc	MSP164757:MJLS_2445-MONOMER.
Family and domain databases
HAMAP	MF_00145. Phosphoglyc_kinase. [Tree]
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
KO	K00927.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_MYCSJ

Accession

Primary (citable) accession number: A3PZA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program