A3PYX7 (APT_MYCSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	Mjls_2318

Organism

Mycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]

Taxonomic identifier

164757 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity. HAMAP MF_00004
Subcellular location	Cytoplasm By similarity HAMAP MF_00004.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_0000329358

Sequences

	Sequence		Length	Mass (Da)
	A3PYX7 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 39685957F3CA21BF	FASTA	174	17,709
	10 20 30 40 50 60 MTDISKVIAS LMREVPDFPE PGIQFKDLTP LLADAEGLMA VTDALAATAE GADLVAGIDA 70 80 90 100 110 120 RGFLLGAAVA LRLGTGVLAV RKGGKLPPPV HSQTYNLEYG SATLEIPADG LDIAGRSVVI 130 140 150 160 170 IDDVLATGGT VAATHRLLTS GGATVLHAAV VLELTALGGR EVVQPLSVSS LYTV

References

[1]

"Complete sequence of Mycobacterium sp. JLS." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JLS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000580 Genomic DNA. Translation: ABN98104.1.
RefSeq	YP_001070595.1. NC_009077.1.
3D structure databases
ProteinModelPortal	A3PYX7.
ModBase	Search...
Protein-protein interaction databases
STRING	A3PYX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000047740; EBMYCP00000046021; EBMYCG00000047735.
GeneID	4878038.
GenomeReviews	Gene locus Mjls_2318 in contig CP000580_GR.
KEGG	mjl:Mjls_2318.
PATRIC	18090774. VBIMycSp51234_2323.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0503.
GeneTree	EBGT00050000016328.
HOGENOM	HBG703830.
OMA	GMEARGF.
PhylomeDB	A3PYX7.
ProtClustDB	PRK02304.
Enzyme and pathway databases
BioCyc	MSP164757:MJLS_2318-MONOMER.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_MYCSJ

Accession

Primary (citable) accession number: A3PYX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program