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A3PVY4 (ADD_MYCSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:Mjls_1259
OrganismMycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]
Taxonomic identifier164757 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Adenosine deaminase HAMAP MF_00540
PRO_1000017670

Sites

Active site2111Proton donor By similarity
Metal binding191Zinc; catalytic By similarity
Metal binding211Zinc; catalytic By similarity
Metal binding2081Zinc; catalytic By similarity
Metal binding3001Zinc; catalytic By similarity
Binding site211Substrate By similarity
Binding site231Substrate By similarity
Binding site1811Substrate; via amide nitrogen and carbonyl oxygen By similarity
Site2321Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A3PVY4 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 9A3AC98A086FB917

FASTA36239,307
        10         20         30         40         50         60 
MTTPLTLENI SQAPKALLHD HLDGGLRPST VLELAGQYGY DDLPADDVDE LATFFRTAAH 

        70         80         90        100        110        120 
SGSLVRYLEP FAHTVGVMQT AEALHRVAFE CVEDLAGDNV VYAEVRFAPE LHIEGGMGLD 

       130        140        150        160        170        180 
AVVDAVLAGF ADGEKAAASA GRTITVRCLV TAMRHAARSR EIAELAIRFR DRGVVGFDIA 

       190        200        210        220        230        240 
GAEAGYPPTR HLDAFEYMRG NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI 

       250        260        270        280        290        300 
TVAPDGQVKL GRLAAILRDK RIPLELCPSS NVQTGAVASI AEHPFDLLAR TRFRVTVNTD 

       310        320        330        340        350        360 
NRLMSDTTMS QEMLRLVEAF GYGWSDLARF TINAMKSSFI PFDERLALID DVIKPRYAVL 


AG

« Hide

References

[1]"Complete sequence of Mycobacterium sp. JLS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JLS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000580 Genomic DNA. Translation: ABN97061.1.
RefSeqYP_001069552.1. NC_009077.1.

3D structure databases

ProteinModelPortalA3PVY4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3PVY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000049132; EBMYCP00000047413; EBMYCG00000049127.
GeneID4876995.
GenomeReviewsGene locus Mjls_1259 in contig CP000580_GR.
KEGGmjl:Mjls_1259.
PATRIC18088638. VBIMycSp51234_1263.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1816.
GeneTreeEBGT00050000016615.
HOGENOMHBG630382.
OMAPYYMAMN.
PhylomeDBA3PVY4.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycMSP164757:MJLS_1259-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_MYCSJ
AccessionPrimary (citable) accession number: A3PVY4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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