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A3PVW1

- A3PVW1_MYCSJ

UniProt

A3PVW1 - A3PVW1_MYCSJ

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Protein
Submitted name: Isocitrate dehydrogenase, NADP-dependent
Gene
Mjls_1236
Organism
Mycobacterium sp. (strain JLS)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarity
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarity
Metal bindingi555 – 5551Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMSP164757:GHV3-1242-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Mjls_1236Imported
OrganismiMycobacterium sp. (strain JLS)Imported
Taxonomic identifieri164757 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000002152: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi164757.Mjls_1236.

Structurei

3D structure databases

ProteinModelPortaliA3PVW1.
SMRiA3PVW1. Positions 6-740.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PVW1-1 [UniParc]FASTAAdd to Basket

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MSAEQPTIIY TLTDEAPLLA TYGFLPIIRT FAGAAGINVE TSDISVAARI    50
LGEFNDRLPE DQRVPDNLAK LGELTQDPAT NIIKLPNISA SVPQLLAAIK 100
ELKAKGYDLP DYPGDPKTDE EKENRARYEK VLGSAVNPVL RQGNSDRRAP 150
KAVKEYAKKH PHSMGEWSMA SRTHVATMRH GDFYHGEKSM TIDRDRKVKM 200
VLETKSGETI VLKPEVKLDE GDIIDSMFMS KKALCEFYEA QMQDAYETGV 250
MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHQKLFDE LGVNVNNGMS 300
DLYSKIEALP ASQREEIIND IHACHETRPE LAMVDSARGI TNFHSPSDVI 350
VDASMPAMIR LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINWCKTNGQ 400
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPEDGVANIV DIDTDEVLLT 450
QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA RASGMTAVFW LDTERPHEAE 500
LRKKVKEYLK DHDTEGLHIQ IMPQVWAMRY TLERVTRGQD TIAVTGNILR 550
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVHQLIEEN 600
HLRWDSLGEF LALGACFEDL GRKTDNKRAA LLGKTMDAAI GKLLDNDKGP 650
SRKTGELDNR GSQFYLAMYW AQELAGQTED KELAEHFAPL AEALVKNEET 700
IVKELAAEQG KSVDIGGYYY PDSEKTTAVM RPSKTLNETL ESASV 745
Length:745
Mass (Da):82,886
Last modified:April 3, 2007 - v1
Checksum:i11E56C31138AFB75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000580 Genomic DNA. Translation: ABN97038.1.
RefSeqiWP_011854906.1. NC_009077.1.
YP_001069529.1. NC_009077.1.

Genome annotation databases

EnsemblBacteriaiABN97038; ABN97038; Mjls_1236.
GeneIDi4876972.
KEGGimjl:Mjls_1236.
PATRICi18088590. VBIMycSp51234_1239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000580 Genomic DNA. Translation: ABN97038.1 .
RefSeqi WP_011854906.1. NC_009077.1.
YP_001069529.1. NC_009077.1.

3D structure databases

ProteinModelPortali A3PVW1.
SMRi A3PVW1. Positions 6-740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164757.Mjls_1236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN97038 ; ABN97038 ; Mjls_1236 .
GeneIDi 4876972.
KEGGi mjl:Mjls_1236.
PATRICi 18088590. VBIMycSp51234_1239.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci MSP164757:GHV3-1242-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JLSImported.

Entry informationi

Entry nameiA3PVW1_MYCSJ
AccessioniPrimary (citable) accession number: A3PVW1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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