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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Mjls_1236

Organism
Mycobacterium sp. (strain JLS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMSP164757:GHV3-1242-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Mjls_1236Imported
OrganismiMycobacterium sp. (strain JLS)Imported
Taxonomic identifieri164757 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000002152 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi164757.Mjls_1236.

Structurei

3D structure databases

ProteinModelPortaliA3PVW1.
SMRiA3PVW1. Positions 6-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PVW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEQPTIIY TLTDEAPLLA TYGFLPIIRT FAGAAGINVE TSDISVAARI
60 70 80 90 100
LGEFNDRLPE DQRVPDNLAK LGELTQDPAT NIIKLPNISA SVPQLLAAIK
110 120 130 140 150
ELKAKGYDLP DYPGDPKTDE EKENRARYEK VLGSAVNPVL RQGNSDRRAP
160 170 180 190 200
KAVKEYAKKH PHSMGEWSMA SRTHVATMRH GDFYHGEKSM TIDRDRKVKM
210 220 230 240 250
VLETKSGETI VLKPEVKLDE GDIIDSMFMS KKALCEFYEA QMQDAYETGV
260 270 280 290 300
MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHQKLFDE LGVNVNNGMS
310 320 330 340 350
DLYSKIEALP ASQREEIIND IHACHETRPE LAMVDSARGI TNFHSPSDVI
360 370 380 390 400
VDASMPAMIR LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINWCKTNGQ
410 420 430 440 450
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPEDGVANIV DIDTDEVLLT
460 470 480 490 500
QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA RASGMTAVFW LDTERPHEAE
510 520 530 540 550
LRKKVKEYLK DHDTEGLHIQ IMPQVWAMRY TLERVTRGQD TIAVTGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVHQLIEEN
610 620 630 640 650
HLRWDSLGEF LALGACFEDL GRKTDNKRAA LLGKTMDAAI GKLLDNDKGP
660 670 680 690 700
SRKTGELDNR GSQFYLAMYW AQELAGQTED KELAEHFAPL AEALVKNEET
710 720 730 740
IVKELAAEQG KSVDIGGYYY PDSEKTTAVM RPSKTLNETL ESASV
Length:745
Mass (Da):82,886
Last modified:April 2, 2007 - v1
Checksum:i11E56C31138AFB75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABN97038.1.
RefSeqiWP_011854906.1. NC_009077.1.
YP_001069529.1. NC_009077.1.

Genome annotation databases

EnsemblBacteriaiABN97038; ABN97038; Mjls_1236.
KEGGimjl:Mjls_1236.
PATRICi18088590. VBIMycSp51234_1239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABN97038.1.
RefSeqiWP_011854906.1. NC_009077.1.
YP_001069529.1. NC_009077.1.

3D structure databases

ProteinModelPortaliA3PVW1.
SMRiA3PVW1. Positions 6-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi164757.Mjls_1236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN97038; ABN97038; Mjls_1236.
KEGGimjl:Mjls_1236.
PATRICi18088590. VBIMycSp51234_1239.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciMSP164757:GHV3-1242-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JLSImported.

Entry informationi

Entry nameiA3PVW1_MYCSJ
AccessioniPrimary (citable) accession number: A3PVW1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 2, 2007
Last sequence update: April 2, 2007
Last modified: March 31, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.