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A3PVW1

- A3PVW1_MYCSJ

UniProt

A3PVW1 - A3PVW1_MYCSJ

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Mjls_1236

Organism
Mycobacterium sp. (strain JLS)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysis
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
    Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciMSP164757:GHV3-1242-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Mjls_1236Imported
    OrganismiMycobacterium sp. (strain JLS)Imported
    Taxonomic identifieri164757 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000002152: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi164757.Mjls_1236.

    Structurei

    3D structure databases

    ProteinModelPortaliA3PVW1.
    SMRiA3PVW1. Positions 6-740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3PVW1-1 [UniParc]FASTAAdd to Basket

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    MSAEQPTIIY TLTDEAPLLA TYGFLPIIRT FAGAAGINVE TSDISVAARI    50
    LGEFNDRLPE DQRVPDNLAK LGELTQDPAT NIIKLPNISA SVPQLLAAIK 100
    ELKAKGYDLP DYPGDPKTDE EKENRARYEK VLGSAVNPVL RQGNSDRRAP 150
    KAVKEYAKKH PHSMGEWSMA SRTHVATMRH GDFYHGEKSM TIDRDRKVKM 200
    VLETKSGETI VLKPEVKLDE GDIIDSMFMS KKALCEFYEA QMQDAYETGV 250
    MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHQKLFDE LGVNVNNGMS 300
    DLYSKIEALP ASQREEIIND IHACHETRPE LAMVDSARGI TNFHSPSDVI 350
    VDASMPAMIR LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINWCKTNGQ 400
    FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPEDGVANIV DIDTDEVLLT 450
    QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA RASGMTAVFW LDTERPHEAE 500
    LRKKVKEYLK DHDTEGLHIQ IMPQVWAMRY TLERVTRGQD TIAVTGNILR 550
    DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVHQLIEEN 600
    HLRWDSLGEF LALGACFEDL GRKTDNKRAA LLGKTMDAAI GKLLDNDKGP 650
    SRKTGELDNR GSQFYLAMYW AQELAGQTED KELAEHFAPL AEALVKNEET 700
    IVKELAAEQG KSVDIGGYYY PDSEKTTAVM RPSKTLNETL ESASV 745
    Length:745
    Mass (Da):82,886
    Last modified:April 3, 2007 - v1
    Checksum:i11E56C31138AFB75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000580 Genomic DNA. Translation: ABN97038.1.
    RefSeqiWP_011854906.1. NC_009077.1.
    YP_001069529.1. NC_009077.1.

    Genome annotation databases

    EnsemblBacteriaiABN97038; ABN97038; Mjls_1236.
    GeneIDi4876972.
    KEGGimjl:Mjls_1236.
    PATRICi18088590. VBIMycSp51234_1239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000580 Genomic DNA. Translation: ABN97038.1 .
    RefSeqi WP_011854906.1. NC_009077.1.
    YP_001069529.1. NC_009077.1.

    3D structure databases

    ProteinModelPortali A3PVW1.
    SMRi A3PVW1. Positions 6-740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 164757.Mjls_1236.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN97038 ; ABN97038 ; Mjls_1236 .
    GeneIDi 4876972.
    KEGGi mjl:Mjls_1236.
    PATRICi 18088590. VBIMycSp51234_1239.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci MSP164757:GHV3-1242-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JLSImported.

    Entry informationi

    Entry nameiA3PVW1_MYCSJ
    AccessioniPrimary (citable) accession number: A3PVW1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3