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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Mycobacterium sp. (strain JLS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMSP164757:GHV3-1005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:Mjls_0997
OrganismiMycobacterium sp. (strain JLS)
Taxonomic identifieri164757 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11721172DNA-directed RNA polymerase subunit betaPRO_0000300350Add
BLAST

Proteomic databases

PRIDEiA3PV78.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi164757.Mjls_0997.

Structurei

3D structure databases

ProteinModelPortaliA3PV78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3PV78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEGCILAVS SQSKSAKAIT NNSVPGAPNR ISFAKLREPL EVPGLLDVQT
60 70 80 90 100
ESFDWLIGAD SWRQRATARG DVNPTGGLEE VLTELSPIED FSGSMSLSFS
110 120 130 140 150
DPRFDEVKAP VDECKDKDMT YAAPLFVTAE FINNNTGEIK SQTVFMGDFP
160 170 180 190 200
MMTEKGTFII NGTERVVVSQ LVRSPGVYFD ESIDKSTEKT LHSVKVIPGR
210 220 230 240 250
GAWLEFDVDK RDTVGVRIDR KRRQPVTVLL KALGWTNEQI TERFGFSEIM
260 270 280 290 300
MSTLEKDNTA GTDEALLDIY RKLRPGEPPT KESAQTLLEN LFFKEKRYDL
310 320 330 340 350
ARVGRYKVNK KLGLNTDKPI TSSTLTEEDV VATIEYLVRL HEGQATMTVP
360 370 380 390 400
GGVEVPVEVD DIDHFGNRRL RTVGELIQNQ IRVGLSRMER VVRERMTTQD
410 420 430 440 450
VEAITPQTLI NIRPVVAAIK EFFGTSQLSQ FMDQNNPLSG LTHKRRLSAL
460 470 480 490 500
GPGGLSRERA GLEVRDVHSS HYGRMCPIET PEGPNIGLIG SLSVYARVNP
510 520 530 540 550
FGFIETPYRK VENGVVTDQI DYLTADEEDR HVVAQANSPL DDEGHFTEDR
560 570 580 590 600
VLVRRKGGEV EFVSATEVDY MDVSPRQMVS VATAMIPFLE HDDANRALMG
610 620 630 640 650
ANMQRQAVPL VRSEAPLVGT GMELRAAIDA GDVVVSEKAG VVEEVSADYI
660 670 680 690 700
TVMADDGTRH TYRMRKFARS NHGTCANQRP IVDAGQRVEA GQVVADGPCT
710 720 730 740 750
QNGEMALGKN LLVAIMPWEG HNYEDAIILS NRLVEEDVLT SIHIEEHEID
760 770 780 790 800
ARDTKLGAEE ITRDIPNVSD EVLADLDERG IVRIGAEVRD GDILVGKVTP
810 820 830 840 850
KGETELTPEE RLLRAIFGEK AREVRDTSLK VPHGESGKVI GIRVFSREDD
860 870 880 890 900
DELPAGVNEL VRVYVAQKRK ISDGDKLAGR HGNKGVIGKI LPVEDMPFLP
910 920 930 940 950
DGTPVDIILN THGVPRRMNI GQILETHLGW VAKAGWNINV AGADGVPDWA
960 970 980 990 1000
EKLPEELYSA PSDSIVATPV FDGARENELS GLLASTLPNR DGDVMVNEDG
1010 1020 1030 1040 1050
KAELFDGRSG EPFPYPVTVG YMYILKLHHL VDDKIHARST GPYSMITQQP
1060 1070 1080 1090 1100
LGGKAQFGGQ RFGEMECWAM QAYGAAYTLQ ELLTIKSDDT VGRVKVYEAI
1110 1120 1130 1140 1150
VKGENIPEPG IPESFKVLLK ELQSLCLNVE VLSSDGAAIE MRDGDDEDLE
1160 1170
RAAANLGINL SRNESASVED LA
Length:1,172
Mass (Da):129,079
Last modified:April 3, 2007 - v1
Checksum:iF84A0673C6D63D81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABN96805.1.
RefSeqiWP_011854801.1. NC_009077.1.

Genome annotation databases

EnsemblBacteriaiABN96805; ABN96805; Mjls_0997.
KEGGimjl:Mjls_0997.
PATRICi18088101. VBIMycSp51234_0995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000580 Genomic DNA. Translation: ABN96805.1.
RefSeqiWP_011854801.1. NC_009077.1.

3D structure databases

ProteinModelPortaliA3PV78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi164757.Mjls_0997.

Proteomic databases

PRIDEiA3PV78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN96805; ABN96805; Mjls_0997.
KEGGimjl:Mjls_0997.
PATRICi18088101. VBIMycSp51234_0995.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Enzyme and pathway databases

BioCyciMSP164757:GHV3-1005-MONOMER.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JLS.

Entry informationi

Entry nameiRPOB_MYCSJ
AccessioniPrimary (citable) accession number: A3PV78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 3, 2007
Last modified: July 6, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.