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A3PU20 (PSD_MYCSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:Mjls_0585
OrganismMycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]
Taxonomic identifier164757 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Phosphatidylserine decarboxylase beta chain By similarity
PRO_1000026656
Chain204 – 23532Phosphatidylserine decarboxylase alpha chain By similarity
PRO_1000026657

Sites

Site203 – 2042Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2041Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
A3PU20 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 1B659F1287AE4A30

FASTA23524,795
        10         20         30         40         50         60 
MARRPSTDDL RSGPERFMAL VKTTVPPVHP AGLPFIGASL ALAAAGRRNR WVRGAGLVAA 

        70         80         90        100        110        120 
GANAAFFRHP PRVPPTRPGV VVAPADGLIC LVEDAEPPAE LNLPARPVPR VSIFLSIFDA 

       130        140        150        160        170        180 
HVQRIPISGE VVAVEHRPGL FGSAELAAAS EDNERNSVVI RTDTGAQVIA VQIAGLVARR 

       190        200        210        220        230 
IVCDLTTGDK VTIGDTYGLI RYGSRLDTYL PEGTDIQVLP GQRAVGGETI LAELP

« Hide

References

[1]"Complete sequence of Mycobacterium sp. JLS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JLS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000580 Genomic DNA. Translation: ABN96397.1.
RefSeqYP_001068888.1. NC_009077.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA3PU20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000052430; EBMYCP00000050711; EBMYCG00000052425.
GeneID4876330.
GenomeReviewsGene locus Mjls_0585 in contig CP000580_GR.
KEGGmjl:Mjls_0585.
PATRIC18087293. VBIMycSp51234_0595.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0688.
GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycMSP164757:MJLS_0585-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCSJ
AccessionPrimary (citable) accession number: A3PU20
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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