Skip Header

Contribute Send feedback
Read comments (?) or add your own

A3PSS2 (ILVD_MYCSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:Mjls_0136
OrganismMycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]
Taxonomic identifier164757 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_0000321598

Sites

Metal binding1421Iron-sulfur (4Fe-4S) Potential
Metal binding2191Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
A3PSS2 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 63FC7EFBC6D6AE9D

FASTA58060,626
        10         20         30         40         50         60 
MPSGSSESPA DALRASDSTP DIKPRSRDVT DGLEKTAARG MLRAVGMGDD DWVKPQIGVG 

        70         80         90        100        110        120 
SSWNEITPCN MSLQRLAQSV KGGVHSAGGF PLEFGTISVS DGISMGHEGM HFSLVSREVI 

       130        140        150        160        170        180 
ADSVETVVQA ERLDGTVLLA GCDKSIPGML MAAARLDLAS VFLYNGSIMP GVAKLTDGSE 

       190        200        210        220        230        240 
REVTIIDAFE AVGACARGLM SREDVDIIER AICPGEGACG GMYTANTMAS AAEALGMSLP 

       250        260        270        280        290        300 
GSASPVAIDK RRDEYARRSG EAVVEMLRRG ITARDILTKE AFENAIAVVM AFGGSTNAVL 

       310        320        330        340        350        360 
HLLAIAWEAN VKLTLEDFTR VGQKVPHLAD VKPFGRHVMK HVDEIGGVPV VMKALLDAGL 

       370        380        390        400        410        420 
MHGDCLTVTG ETMAENLAHI EPPDPDGKVL RAMNNPIHPT GGITILHGSL APEGAVVKSA 

       430        440        450        460        470        480 
GFDSDVFEGT ARVFERERAA LDALEDGTIT HGDVVVIRYE GPKGGPGMRE MLAITGAIKG 

       490        500        510        520        530        540 
AGLGKDVLLM TDGRFSGGTT GLCVGHIAPE AVDGGPIAFV RDGDRIRLDV AKGTLDLLVD 

       550        560        570        580 
EAEFESRKAG FEPLPPVYTT GVLAKYTKLV GSAAVGAVCG

« Hide

References

[1]"Complete sequence of Mycobacterium sp. JLS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JLS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000580 Genomic DNA. Translation: ABN95949.1.
RefSeqYP_001068440.1. NC_009077.1.

3D structure databases

ProteinModelPortalA3PSS2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3PSS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000048781; EBMYCP00000047062; EBMYCG00000048776.
GeneID4875882.
GenomeReviewsGene locus Mjls_0136 in contig CP000580_GR.
KEGGmjl:Mjls_0136.
PATRIC18086377. VBIMycSp51234_0138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0129.
GeneTreeEBGT00050000016366.
HOGENOMHBG671001.
OMANMPGAMI.
PhylomeDBA3PSS2.
ProtClustDBPRK00911.

Enzyme and pathway databases

BioCycMSP164757:MJLS_0136-MONOMER.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_MYCSJ
AccessionPrimary (citable) accession number: A3PSS2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 3, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents