A3PSE3 (A3PSE3_MYCSJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	Mjls_0007

Organism

Mycobacterium sp. (strain JLS) [Complete proteome] [HAMAP]

Taxonomic identifier

164757 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3PSE3 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: B7A92A543681FA3D	FASTA	836	92,572
	10 20 30 40 50 60 MTDTTLPPGD EAGDRIEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM 70 80 90 100 110 120 FDSGFRPDRG HAKSARSVAE TMGNYHPHGD SSIYDTLVRM AQPWSLRYPL VDGQGNFGSP 130 140 150 160 170 180 GNDPPAAMRY TEARLTPLAM EMLREIDEET VDFIPNYDGR VQEPTVLPSR FPNLLANGSG 190 200 210 220 230 240 GIAVGMATNI PPHNLRELAD AVYWCLENFE ADEETTLAAV MERVKGPDFP THGLIVGSQG 250 260 270 280 290 300 IEDTYKTGRG SVKMRGVVEI EEDSRGRTGI VITELPYQVN HDNFITSIAE QVRDGKLAGI 310 320 330 340 350 360 SNIEDQSSDR VGLRIVVELK RDAVAKVVLN NLYKHTQLQT SFGANMLSIV DGVPRTLRLD 370 380 390 400 410 420 QMIRYYVEHQ LDVIVRRTRY RLRKANERAH ILRGLVKALD ALDEVIALIR ASQTVDIARA 430 440 450 460 470 480 GLIELLDIDE IQAQAILDMQ LRRLAALERQ RIVDDLAKIE AEIADLEDIL AKPERQRAIV 490 500 510 520 530 540 RDELKEIADK YGDDRRTRIV PADGEVSDED LIAREDVVVT ITETGYAKRT KTDLYRSQKR 550 560 570 580 590 600 GGKGVQGAGL KQDDIVNHFF VCSTHDWILF FTTQGRVYRA KAYELPEASR TARGQHVANL 610 620 630 640 650 660 LAFQPNERIA QVIQIKSYED APYLVLATRN GLVKKSRLTD FDSNRSGGIV AVNLRDGDEL 670 680 690 700 710 720 VGAVLCSSED DLLLVSAKGQ SIRFSATDEA LRPMGRATSG VQGMRFNADD ELLSLNVVRP 730 740 750 760 770 780 DTYLLVATSG GYAKRTSIEE YTAQGRGGKG ILTIQYDRRR GNLVGALIVD DDTELYAITS 790 800 810 820 830 GGGVIRTAAR QVRKAGRQTK GVRLMNLGEG DTLIAIARNA EAGDSTDEVN TDPDAV

References

[1]

"Complete sequence of Mycobacterium sp. JLS." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J., Sims R.C., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JLS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000580 Genomic DNA. Translation: ABN95820.1.
RefSeq	YP_001068311.1. NC_009077.1.
3D structure databases
ProteinModelPortal	A3PSE3.
ModBase	Search...
Protein-protein interaction databases
STRING	A3PSE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000047672; EBMYCP00000045953; EBMYCG00000047667.
GeneID	4875753.
GenomeReviews	Gene locus Mjls_0007 in contig CP000580_GR.
KEGG	mjl:Mjls_0007.
PATRIC	18086109. VBIMycSp51234_0007.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
GeneTree	EBGT00050000016653.
HOGENOM	HBG635183.
OMA	TGRGRIY.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3PSE3_MYCSJ

Accession

Primary (citable) accession number: A3PSE3

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)