A3PRX7 (IOLG_RHOS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Rsph17029_4015

Organism

Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) [Complete proteome] [HAMAP]

Taxonomic identifier

349101 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352587

Sequences

	Sequence		Length	Mass (Da)
	A3PRX7 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 17BDE2CEDC26BA02	FASTA	334	36,104
	10 20 30 40 50 60 MTLRIGIIGT GAIGTDHARR INRVLSGAEV TAVTDVNRDN AEACVAGVAP GAQILGSAEE 70 80 90 100 110 120 VIAASDAVLV CSWGAAHEAQ VLAAIAAGKP CFCEKPLATE AYGARRIVEA EGAMGRRLVQ 130 140 150 160 170 180 VGFMRRYDRG YIALKETVRT RLGPPLMIHA AHRNPTVPGR YRTPMAIHDT LIHEIDVLRW 190 200 210 220 230 240 LLDDEYVSAQ VIFPRATRHT HAGLRDPQIV LLETAKGVRI DVEIFVNCRY GYDIQCEVVG 250 260 270 280 290 300 EEGTARLPEP MAIPTRLGAM FGQPILMDWK DRFIDSYDVE LQDFLKAAAQ GTAAGPSAWD 310 320 330 GYAAAITADV CVQAQERPGA ILPVTLPARP ALYA

References

[1]

"Complete sequence of chromosome 2 of Rhodobacter sphaeroides ATCC 17029." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17029 / ATH 2.4.9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000578 Genomic DNA. Translation: ABN79093.1.
RefSeq	YP_001045865.1. NC_009050.1.
3D structure databases
ProteinModelPortal	A3PRX7.
ModBase	Search...
Protein-protein interaction databases
STRING	A3PRX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4898568.
GenomeReviews	Gene locus Rsph17029_4015 in contig CP000578_GR.
KEGG	rsh:Rsph17029_4015.
PATRIC	23176079. VBIRhoSph114483_4300.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK800746.
Enzyme and pathway databases
BioCyc	RSPH349101:RSPH17029_4015-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RHOS1

Accession

Primary (citable) accession number: A3PRX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program