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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

Rsph17029_3393

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (Rsph17029_3393)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciRSPH349101:GHC8-3417-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:Rsph17029_3393
OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Taxonomic identifieri349101 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002606 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000620441 – 301Probable 5-dehydro-4-deoxyglucarate dehydrataseAdd BLAST301

Structurei

3D structure databases

ProteinModelPortaliA3PQ70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000173605.
KOiK01707.
OMAiFMAIRNR.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PQ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQQIKAAL GSGLLSFPVT PFDAENRFAA APYQKHVEWL SGFDAPVLFA
60 70 80 90 100
AGGTGEFFSL TPDEIPAIVR AAKESAGKTA IVSGCGYGTE IARGIARSVE
110 120 130 140 150
AAGGDGILLL PHYLIDAPQE GLYAHVKAVC QATGMGVMVY NRDNAVLQAD
160 170 180 190 200
TLARLCDDCP NLVGFKDGTG DIGLVRQITA KMGDRLTYLG GMPTAELFAE
210 220 230 240 250
AYLGASFTTY SSAVFNFVPA LANKFYAALR AGDRATCESI LNSFFYPFME
260 270 280 290 300
LRSRRKGYAV AAVKAGVRLV GFDAGPVRAP LSDLTGEEEE ILKALIDAHR

E
Length:301
Mass (Da):32,004
Last modified:April 3, 2007 - v1
Checksum:i4E9CD8633FFED28B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000578 Genomic DNA. Translation: ABN78486.1.
RefSeqiWP_011842331.1. NC_009050.1.

Genome annotation databases

EnsemblBacteriaiABN78486; ABN78486; Rsph17029_3393.
KEGGirsh:Rsph17029_3393.
PATRICi23174735. VBIRhoSph114483_3650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000578 Genomic DNA. Translation: ABN78486.1.
RefSeqiWP_011842331.1. NC_009050.1.

3D structure databases

ProteinModelPortaliA3PQ70.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN78486; ABN78486; Rsph17029_3393.
KEGGirsh:Rsph17029_3393.
PATRICi23174735. VBIRhoSph114483_3650.

Phylogenomic databases

HOGENOMiHOG000173605.
KOiK01707.
OMAiFMAIRNR.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.
BioCyciRSPH349101:GHC8-3417-MONOMER.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDGD_RHOS1
AccessioniPrimary (citable) accession number: A3PQ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.