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Protein

Phosphoglycolate phosphatase

Gene

cbbZ

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (cbbZ)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei7NucleophileUniRule annotation1
Metal bindingi7MagnesiumUniRule annotation1
Metal bindingi9MagnesiumUniRule annotation1
Metal bindingi167MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCalvin cycle, Carbohydrate metabolism, Photosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:cbbZUniRule annotation
Ordered Locus Names:Rsph17029_2937
OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Taxonomic identifieri349101 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002606 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000505951 – 218Phosphoglycolate phosphataseAdd BLAST218

Structurei

3D structure databases

ProteinModelPortaliA3PNX3
SMRiA3PNX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248344
KOiK01091
OMAiPTHPESA

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_00495 GPH_hydrolase_bact, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
IPR006346 PGPase/MupP
IPR037512 PGPase_prok
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01549 HAD-SF-IA-v1, 1 hit
TIGR01449 PGP_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A3PNX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVVFDLDG TLVHSAPDIH AAVNKALAEE GGAPFTLAEI TGFIGNGVPV
60 70 80 90 100
LIQRVLAARG EAPDAHRQAE LQGRFMAHYE ADPATLTSVY PGAEAAIRHL
110 120 130 140 150
RAEGWRIGLC TNKPVGASRQ ILSLFGLLEL FDAIIGGDSL PQRKPDPAPL
160 170 180 190 200
RATAAALNEE VVLYVGDSEV DAATAEAAGL RFALFTEGYR HAPVHELPHH
210
GLFSHHDELP DLLRRLLA
Length:218
Mass (Da):23,279
Last modified:April 3, 2007 - v1
Checksum:i60DDC9CB039FFA33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA Translation: ABN78039.1
RefSeqiWP_002721819.1, NC_009049.1

Genome annotation databases

EnsemblBacteriaiABN78039; ABN78039; Rsph17029_2937
KEGGirsh:Rsph17029_2937

Similar proteinsi

Entry informationi

Entry nameiGPH_RHOS1
AccessioniPrimary (citable) accession number: A3PNX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health