Reviewed, UniProtKB/Swiss-Prot A3PMI4 (PQQC_RHOS1)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	Rsph17029_2448

Organism

Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) [Complete proteome] [HAMAP]

Taxonomic identifier

349101 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity.
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_1000061677

Sequences

	Sequence		Length	Mass (Da)
	A3PMI4-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 62D2821B96B7EF16	FASTA	255	29,090
	10 20 30 40 50 60 MSLDLSTSLS PARPLESADA MEERLREIGA ARYHDRHPFH HMLHGGELTK GQVQAWALNR 70 80 90 100 110 120 YYYQCTIPVK DAVVISRFRD RATRIEWRHR LEDHDGAEGA EGGIDRWLIL TDGLGLDRAY 130 140 150 160 170 180 VESTDGILPA TRFAVEAYVH FVRDRSPLEA IASCLTELFA PNIHATRISG MLSHYDFINP 190 200 210 220 230 240 TVMAYFQRRL TQAPRDADYA LRYVRDHART PEERAAVCNA LIFKTQVLWT QLDALHHAYV 250 LGHVPPGAFV PEEMR

References

[1]

"Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000577 Genomic DNA. Translation: ABN77550.1.
RefSeq	YP_001044322.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4897720.
GenomeReviews	Gene locus Rsph17029_2448 in contig CP000577_GR.
KEGG	rsh:Rsph17029_2448.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A3PMI4. AWALNRY.
Family and domain databases
HAMAP	MF_00654. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_RHOS1

Accession

Primary (citable) accession number: A3PMI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 3, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)