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A3PM52

- FTHS_RHOS1

UniProt

A3PM52 - FTHS_RHOS1

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSPH349101:GHC8-2353-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Rsph17029_2316
    OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
    Taxonomic identifieri349101 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002606: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000300535Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349101.Rsph17029_2316.

    Structurei

    3D structure databases

    ProteinModelPortaliA3PM52.
    SMRiA3PM52. Positions 6-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3PM52-1 [UniParc]FASTAAdd to Basket

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    MAVQTDIEIA RAARKKPIQE IGAGLGIPAE ALIPYGHDKA KVGQGFIRGL    50
    EGRPDGKLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKK AVICIREASL 100
    GPNFGMKGGA AGGGRAQVVP MEDMNLHFTG DFHAITAAHN LLAAMIDNHI 150
    YWGNALELDA RRITWRRVMD MNDRALRDTV VNLGGVANGF PRQTGFDITV 200
    ASEVMAILCL ADDLEDLERR LGRIVVGYRR DKSPVYCRDL KAAGAMAVLL 250
    KDAMQPNLVQ TIENNPAFVH GGPFANIAHG CNSVIATRTA LKLADYVVTE 300
    AGFGADLGAE KFFDIKCRLA GLKPSAAVVV ATVRALKMNG GVAREDLGRE 350
    DVAALRRGCA NLGRHIANVK GFGVPVVVAI NHFTTDTEAE IEAVRAYAAG 400
    QGAEAFLCRH WAEGSAGIED LAQKVVELAE TPSMFAPLYP DDMPLFEKME 450
    TVARRIYHAH DVIADHVIRD QLRTWEEAGY GALPVCMAKT QYSFTTDAAI 500
    RGAPEGHSIP IREVRLAAGA GFVVAICGEI RTMPGLPSQP AAELIHLDEE 550
    GRIEGLF 557
    Length:557
    Mass (Da):59,619
    Last modified:April 3, 2007 - v1
    Checksum:i70FA3F19090AF783
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000577 Genomic DNA. Translation: ABN77418.1.
    RefSeqiYP_001044190.1. NC_009049.1.

    Genome annotation databases

    EnsemblBacteriaiABN77418; ABN77418; Rsph17029_2316.
    GeneIDi4895996.
    KEGGirsh:Rsph17029_2316.
    PATRICi23172485. VBIRhoSph114483_2535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000577 Genomic DNA. Translation: ABN77418.1 .
    RefSeqi YP_001044190.1. NC_009049.1.

    3D structure databases

    ProteinModelPortali A3PM52.
    SMRi A3PM52. Positions 6-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349101.Rsph17029_2316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN77418 ; ABN77418 ; Rsph17029_2316 .
    GeneIDi 4895996.
    KEGGi rsh:Rsph17029_2316.
    PATRICi 23172485. VBIRhoSph114483_2535.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RSPH349101:GHC8-2353-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
      , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17029 / ATH 2.4.9.

    Entry informationi

    Entry nameiFTHS_RHOS1
    AccessioniPrimary (citable) accession number: A3PM52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3