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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH349101:GHC8-2273-MONOMER.
UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:Rsph17029_2239
OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Taxonomic identifieri349101 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002606 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Probable nicotinate-nucleotide adenylyltransferasePRO_0000310136Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA3PLX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262782.
KOiK00969.
OMAiPLKSRNQ.
OrthoDBiEOG6F55KJ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PLX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGLLGGSF DPPHPGHVHI TREALKRFGL DRVWWLVSPG NPLKPRPPAP
60 70 80 90 100
LARRLAEARR LMRHPRVAVT GLEAEIGTRF TAETLAVLQR RYPGVRFVWL
110 120 130 140 150
MGADNLAQFH RWERWRAIME SVPVGVLARP GAGLRARTSP AARRYASALL
160 170 180 190
PEAEAARLGR SAAPAWCFVN LPMMDLSSTE IRATGRWRGQ AD
Length:192
Mass (Da):21,379
Last modified:April 3, 2007 - v1
Checksum:i550B6A6051E30CC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN77342.1.
RefSeqiWP_011841534.1. NC_009049.1.

Genome annotation databases

EnsemblBacteriaiABN77342; ABN77342; Rsph17029_2239.
KEGGirsh:Rsph17029_2239.
PATRICi23172317. VBIRhoSph114483_2454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN77342.1.
RefSeqiWP_011841534.1. NC_009049.1.

3D structure databases

ProteinModelPortaliA3PLX6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN77342; ABN77342; Rsph17029_2239.
KEGGirsh:Rsph17029_2239.
PATRICi23172317. VBIRhoSph114483_2454.

Phylogenomic databases

HOGENOMiHOG000262782.
KOiK00969.
OMAiPLKSRNQ.
OrthoDBiEOG6F55KJ.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.
BioCyciRSPH349101:GHC8-2273-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17029 / ATH 2.4.9.

Entry informationi

Entry nameiNADD_RHOS1
AccessioniPrimary (citable) accession number: A3PLX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 3, 2007
Last modified: December 9, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.