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Protein

4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

Gene

kduI

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotation

Catalytic activityi

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: pectin degradation

This protein is involved in step 4 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (kduI)
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi192 – 1921ZincUniRule annotation
Metal bindingi194 – 1941ZincUniRule annotation
Metal bindingi199 – 1991ZincUniRule annotation
Metal bindingi241 – 2411ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciRSPH349101:GHC8-2168-MONOMER.
UniPathwayiUPA00545; UER00826.

Names & Taxonomyi

Protein namesi
Recommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomeraseUniRule annotation (EC:5.3.1.17UniRule annotation)
Alternative name(s):
5-keto-4-deoxyuronate isomeraseUniRule annotation
DKI isomeraseUniRule annotation
Gene namesi
Name:kduIUniRule annotation
Ordered Locus Names:Rsph17029_2134
OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Taxonomic identifieri349101 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002606 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742744-deoxy-L-threo-5-hexosulose-uronate ketol-isomerasePRO_1000045085Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA3PLM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KduI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000124379.
KOiK01815.
OMAiIWAMAGE.
OrthoDBiEOG664CJZ.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PLM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHVEIRHAM DPVSARQLDT AGLREAFHMG DLFRSGEIRL VYTHYDRMIV
60 70 80 90 100
GGAVPAGEPL VLDEVKPTGT ASILDRREMG VVNVGAAGTV SAGGESWEMG
110 120 130 140 150
RGDVLYLPMG AGPVTFAGEG RFYILSAPAH TAHPARLVKL EDAKKVKLGS
160 170 180 190 200
PETANERTIN QFIHPEVMQS CQLVVGYTQF HGGSVWNTMP AHVHDRRMEA
210 220 230 240 250
YLYFDLAEEA RVFHFMGEPS ETRHLVMRNE EAVVSPPWSI HCGCGTGSYT
260 270
FVWAMAGDNV DYRDVEMVAM EDLR
Length:274
Mass (Da):30,263
Last modified:April 3, 2007 - v1
Checksum:i9363E16BED39983B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN77237.1.
RefSeqiWP_002720646.1. NC_009049.1.

Genome annotation databases

EnsemblBacteriaiABN77237; ABN77237; Rsph17029_2134.
KEGGirsh:Rsph17029_2134.
PATRICi23172094. VBIRhoSph114483_2343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN77237.1.
RefSeqiWP_002720646.1. NC_009049.1.

3D structure databases

ProteinModelPortaliA3PLM1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN77237; ABN77237; Rsph17029_2134.
KEGGirsh:Rsph17029_2134.
PATRICi23172094. VBIRhoSph114483_2343.

Phylogenomic databases

HOGENOMiHOG000124379.
KOiK01815.
OMAiIWAMAGE.
OrthoDBiEOG664CJZ.

Enzyme and pathway databases

UniPathwayiUPA00545; UER00826.
BioCyciRSPH349101:GHC8-2168-MONOMER.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17029 / ATH 2.4.9.

Entry informationi

Entry nameiKDUI_RHOS1
AccessioniPrimary (citable) accession number: A3PLM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.