ID   A3PLI2_CERS1            Unreviewed;       348 AA.
AC   A3PLI2;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Cysteine desulfurase {ECO:0000256|ARBA:ARBA00013558};
GN   ORFNames=Rsph17029_2095 {ECO:0000313|EMBL:ABN77198.1};
OS   Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Cereibacter.
OX   NCBI_TaxID=349101 {ECO:0000313|EMBL:ABN77198.1};
RN   [1] {ECO:0000313|EMBL:ABN77198.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 17029 {ECO:0000313|EMBL:ABN77198.1};
RX   PubMed=17172323;
RA   Choudhary M., Zanhua X., Fu Y.X., Kaplan S.;
RT   "Genome analyses of three strains of Rhodobacter sphaeroides: evidence of
RT   rapid evolution of chromosome II.";
RL   J. Bacteriol. 189:1914-1921(2007).
RN   [2] {ECO:0000313|EMBL:ABN77198.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 17029 {ECO:0000313|EMBL:ABN77198.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.,
RA   Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of Chromosome1 of Rhodobacter sphaeroides ATCC 17029.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-
CC         alanine; Xref=Rhea:RHEA:43892, Rhea:RHEA-COMP:14737, Rhea:RHEA-
CC         COMP:14739, ChEBI:CHEBI:29917, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972,
CC         ChEBI:CHEBI:64428; EC=2.8.1.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00001357};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC       aminotransferase family. NifS/IscS subfamily.
CC       {ECO:0000256|ARBA:ARBA00006490}.
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DR   EMBL; CP000577; ABN77198.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3PLI2; -.
DR   KEGG; rsh:Rsph17029_2095; -.
DR   HOGENOM; CLU_003433_0_0_5; -.
DR   GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.260.50; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000192; Aminotrans_V_dom.
DR   InterPro; IPR016454; Cysteine_dSase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR   Pfam; PF00266; Aminotran_5; 2.
DR   PIRSF; PIRSF005572; NifS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Transferase {ECO:0000313|EMBL:ABN77198.1}.
FT   DOMAIN          5..81
FT                   /note="Aminotransferase class V"
FT                   /evidence="ECO:0000259|Pfam:PF00266"
FT   DOMAIN          137..328
FT                   /note="Aminotransferase class V"
FT                   /evidence="ECO:0000259|Pfam:PF00266"
SQ   SEQUENCE   348 AA;  35937 MW;  B46DEB223B075FD0 CRC64;
     MGSRVYLDWN ATAPLRAEAR AAMLEAMDLV GNPSSVHAEG RRARALVERA RAQVAAALGA
     EGADVVFVSG ATEAAALACA GRGLFCADVE HEAVSAWCAP ELAVDASGRV AVAEPGRSAL
     QLANSETGIL QDLPEGLAVS DLTQAFGKVP FAFNWLGCAM GFVSAHKIGG PKGVGALVIR
     RGLDLEARIK GGGQEMGRRA GTENLIGIAG FGAAAEAAAR DLAEGLWEPV LQLRNILESA
     LCDDGKGTIS VGKAVPRLPN TLCLVTPGWK GETQVMQMDL AGFAVSAGSA CSSGKVRASR
     VLRAMGLGEE EAGSALRLSL GPGVTEAEGL RFAEAWMRAR DRHRARAA
//