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A3PJS2 (AROB_RHOS1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Rsph17029_1478
OrganismRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) [Complete proteome] [HAMAP]
Taxonomic identifier349101 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3703703-dehydroquinate synthase HAMAP MF_00110
PRO_1000094588

Sequences

Sequence LengthMass (Da)Tools
A3PJS2 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 7710A12B2E56FB93

FASTA37039,513
        10         20         30         40         50         60 
MTVDAVRVEL GARAYEVRIG PGLIARAGAE IAPLLRRPKV AILTDETVAG LHLDPFRQAL 

        70         80         90        100        110        120 
AEAGIASSAL ALPAGEATKG WPQFARAVEW LLEEKVERRD VVVALGGGVI GDLAGFAAAV 

       130        140        150        160        170        180 
LRRGVRFVQV PTTLLAQVDS SVGGKTGINT AQGKNLVGAF HQPSLVLADI GVLETLPPRD 

       190        200        210        220        230        240 
FRAGYGEVVK YGLLGDADFY EWLEEAGPRL AADTEARQRA VRRSVEMKAE IVARDETEEG 

       250        260        270        280        290        300 
DRALLNLGHT FCHALEKATG YSDRLLHGEG VAIGCALAFE LSQRLGLCAQ EAPSRLRAHL 

       310        320        330        340        350        360 
RAMGMKVDLR DIPGDLPSAE ALLALMAQDK KVVDGKLRFI LARGIGQAFV ADDVPGDVVR 

       370 
TLLEDALAQR

« Hide

References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17029 / ATH 2.4.9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000577 Genomic DNA. Translation: ABN76588.1.
RefSeqYP_001043360.1. NC_009049.1.

3D structure databases

ProteinModelPortalA3PJS2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3PJS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4895071.
GenomeReviewsGene locus Rsph17029_1478 in contig CP000577_GR.
KEGGrsh:Rsph17029_1478.
PATRIC23170724. VBIRhoSph114483_1669.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycRSPH349101:RSPH17029_1478-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_RHOS1
AccessionPrimary (citable) accession number: A3PJS2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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