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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRSPH349101:GHC8-887-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Rsph17029_0870
OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Taxonomic identifieri349101 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002606 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956Glycine dehydrogenase (decarboxylating)PRO_1000045602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei697 – 6971N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi349101.Rsph17029_0870.

Structurei

3D structure databases

ProteinModelPortaliA3PI15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PI15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFTPTDYNA YDFANRRHIG PSPSEMEEML RVVGVSSLDQ LIEETVPASI
60 70 80 90 100
RQETPLDWAP LAEHELLARM REVAGKNRVM TSLIGQGYYG TVTPPAIQRN
110 120 130 140 150
ILENPAWYTA YTPYQPEIAQ GRLEALLNYQ TMVADLTGLP VANASLLDEA
160 170 180 190 200
TAAAEAMTMA ERASKSKARA FFVDADCHPQ TISVIRTRAE PLGIEVIVGH
210 220 230 240 250
PAQLVPEDVF GALFQYPGTY GLVRDFTRDI AALHEAKALA VVATDLLALC
260 270 280 290 300
LLKEPGAMGA DIAIGSSQRF GVPMGYGGPH AAFMSCKDDL KRSMPGRLVG
310 320 330 340 350
VSVDARGNKA YRLALQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG
360 370 380 390 400
PRGLRAIAER VHLNTVRLAT ALKEAGARVS PEAFFDTITV EVGVGQAGIL
410 420 430 440 450
AAARHRGINL RKVGRDRVGI SLDETTDAGV IARVLDAFGI HEPAPAKVGL
460 470 480 490 500
GFPEPLLRET GYLSHPVFQM NRAESEMMRY MRRLSDRDLA LDRAMIPLGS
510 520 530 540 550
CTMKLNAAAE MMPITWPEFG TLHPFAPADQ AAGYHEAIGD LAQRLCRITG
560 570 580 590 600
YDAMSMQPNS GAQGEYAGLL TILAYHRARG EAERTICLIP VSAHGTNPAS
610 620 630 640 650
AQMAGMKVVV VKSAPNGDVD LEDFRDKAAA AGDRLAACMI TYPSTHGVFE
660 670 680 690 700
ETVREVCRIT HEHGGQVYID GANMNAMVGL VQPGAIGGDV SHLNLHKTFA
710 720 730 740 750
IPHGGGGPGM GPIGVKAHLA PYLPGHPEVT GPLTGGHDEA ADEGPVSAAP
760 770 780 790 800
YGSASILLIS WAYCLMMGGE GLTQATRVAI LNANYIAARL RGAYKVLFMG
810 820 830 840 850
NRGRVAHECI LDTRPFAEAG VTVDDIAKRL IDNGFHAPTM SWPVPGTLMV
860 870 880 890 900
EPTESETKAE IDRFVAALLA IREEIRAVEE GEIAAGDSPL RHAPHTVEDL
910 920 930 940 950
VADWDRKYPR EQGCFPPGSF RVDKYWPPVG RVDNAWGDRN LVCTCPPVES

YSIAAQ
Length:956
Mass (Da):103,072
Last modified:April 3, 2007 - v1
Checksum:i4671F169C036BEF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN75981.1.
RefSeqiWP_011840655.1. NC_009049.1.
YP_001042753.1. NC_009049.1.

Genome annotation databases

EnsemblBacteriaiABN75981; ABN75981; Rsph17029_0870.
KEGGirsh:Rsph17029_0870.
PATRICi23169434. VBIRhoSph114483_1029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN75981.1.
RefSeqiWP_011840655.1. NC_009049.1.
YP_001042753.1. NC_009049.1.

3D structure databases

ProteinModelPortaliA3PI15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349101.Rsph17029_0870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN75981; ABN75981; Rsph17029_0870.
KEGGirsh:Rsph17029_0870.
PATRICi23169434. VBIRhoSph114483_1029.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciRSPH349101:GHC8-887-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17029 / ATH 2.4.9.

Entry informationi

Entry nameiGCSP_RHOS1
AccessioniPrimary (citable) accession number: A3PI15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: April 29, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.