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A3PI15

- GCSP_RHOS1

UniProt

A3PI15 - GCSP_RHOS1

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRSPH349101:GHC8-887-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Rsph17029_0870
    OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
    Taxonomic identifieri349101 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002606: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 956956Glycine dehydrogenase (decarboxylating)PRO_1000045602Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei697 – 6971N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi349101.Rsph17029_0870.

    Structurei

    3D structure databases

    ProteinModelPortaliA3PI15.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3PI15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFTPTDYNA YDFANRRHIG PSPSEMEEML RVVGVSSLDQ LIEETVPASI    50
    RQETPLDWAP LAEHELLARM REVAGKNRVM TSLIGQGYYG TVTPPAIQRN 100
    ILENPAWYTA YTPYQPEIAQ GRLEALLNYQ TMVADLTGLP VANASLLDEA 150
    TAAAEAMTMA ERASKSKARA FFVDADCHPQ TISVIRTRAE PLGIEVIVGH 200
    PAQLVPEDVF GALFQYPGTY GLVRDFTRDI AALHEAKALA VVATDLLALC 250
    LLKEPGAMGA DIAIGSSQRF GVPMGYGGPH AAFMSCKDDL KRSMPGRLVG 300
    VSVDARGNKA YRLALQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG 350
    PRGLRAIAER VHLNTVRLAT ALKEAGARVS PEAFFDTITV EVGVGQAGIL 400
    AAARHRGINL RKVGRDRVGI SLDETTDAGV IARVLDAFGI HEPAPAKVGL 450
    GFPEPLLRET GYLSHPVFQM NRAESEMMRY MRRLSDRDLA LDRAMIPLGS 500
    CTMKLNAAAE MMPITWPEFG TLHPFAPADQ AAGYHEAIGD LAQRLCRITG 550
    YDAMSMQPNS GAQGEYAGLL TILAYHRARG EAERTICLIP VSAHGTNPAS 600
    AQMAGMKVVV VKSAPNGDVD LEDFRDKAAA AGDRLAACMI TYPSTHGVFE 650
    ETVREVCRIT HEHGGQVYID GANMNAMVGL VQPGAIGGDV SHLNLHKTFA 700
    IPHGGGGPGM GPIGVKAHLA PYLPGHPEVT GPLTGGHDEA ADEGPVSAAP 750
    YGSASILLIS WAYCLMMGGE GLTQATRVAI LNANYIAARL RGAYKVLFMG 800
    NRGRVAHECI LDTRPFAEAG VTVDDIAKRL IDNGFHAPTM SWPVPGTLMV 850
    EPTESETKAE IDRFVAALLA IREEIRAVEE GEIAAGDSPL RHAPHTVEDL 900
    VADWDRKYPR EQGCFPPGSF RVDKYWPPVG RVDNAWGDRN LVCTCPPVES 950
    YSIAAQ 956
    Length:956
    Mass (Da):103,072
    Last modified:April 3, 2007 - v1
    Checksum:i4671F169C036BEF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000577 Genomic DNA. Translation: ABN75981.1.
    RefSeqiWP_011840655.1. NC_009049.1.
    YP_001042753.1. NC_009049.1.

    Genome annotation databases

    EnsemblBacteriaiABN75981; ABN75981; Rsph17029_0870.
    GeneIDi4896994.
    KEGGirsh:Rsph17029_0870.
    PATRICi23169434. VBIRhoSph114483_1029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000577 Genomic DNA. Translation: ABN75981.1 .
    RefSeqi WP_011840655.1. NC_009049.1.
    YP_001042753.1. NC_009049.1.

    3D structure databases

    ProteinModelPortali A3PI15.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349101.Rsph17029_0870.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN75981 ; ABN75981 ; Rsph17029_0870 .
    GeneIDi 4896994.
    KEGGi rsh:Rsph17029_0870.
    PATRICi 23169434. VBIRhoSph114483_1029.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RSPH349101:GHC8-887-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
      , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17029 / ATH 2.4.9.

    Entry informationi

    Entry nameiGCSP_RHOS1
    AccessioniPrimary (citable) accession number: A3PI15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3