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A3PI15

- GCSP_RHOS1

UniProt

A3PI15 - GCSP_RHOS1

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Rsph17029_0870
Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRSPH349101:GHC8-887-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Rsph17029_0870
OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Taxonomic identifieri349101 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002606: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei697 – 6971N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi349101.Rsph17029_0870.

Structurei

3D structure databases

ProteinModelPortaliA3PI15.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PI15-1 [UniParc]FASTAAdd to Basket

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MSFTPTDYNA YDFANRRHIG PSPSEMEEML RVVGVSSLDQ LIEETVPASI    50
RQETPLDWAP LAEHELLARM REVAGKNRVM TSLIGQGYYG TVTPPAIQRN 100
ILENPAWYTA YTPYQPEIAQ GRLEALLNYQ TMVADLTGLP VANASLLDEA 150
TAAAEAMTMA ERASKSKARA FFVDADCHPQ TISVIRTRAE PLGIEVIVGH 200
PAQLVPEDVF GALFQYPGTY GLVRDFTRDI AALHEAKALA VVATDLLALC 250
LLKEPGAMGA DIAIGSSQRF GVPMGYGGPH AAFMSCKDDL KRSMPGRLVG 300
VSVDARGNKA YRLALQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG 350
PRGLRAIAER VHLNTVRLAT ALKEAGARVS PEAFFDTITV EVGVGQAGIL 400
AAARHRGINL RKVGRDRVGI SLDETTDAGV IARVLDAFGI HEPAPAKVGL 450
GFPEPLLRET GYLSHPVFQM NRAESEMMRY MRRLSDRDLA LDRAMIPLGS 500
CTMKLNAAAE MMPITWPEFG TLHPFAPADQ AAGYHEAIGD LAQRLCRITG 550
YDAMSMQPNS GAQGEYAGLL TILAYHRARG EAERTICLIP VSAHGTNPAS 600
AQMAGMKVVV VKSAPNGDVD LEDFRDKAAA AGDRLAACMI TYPSTHGVFE 650
ETVREVCRIT HEHGGQVYID GANMNAMVGL VQPGAIGGDV SHLNLHKTFA 700
IPHGGGGPGM GPIGVKAHLA PYLPGHPEVT GPLTGGHDEA ADEGPVSAAP 750
YGSASILLIS WAYCLMMGGE GLTQATRVAI LNANYIAARL RGAYKVLFMG 800
NRGRVAHECI LDTRPFAEAG VTVDDIAKRL IDNGFHAPTM SWPVPGTLMV 850
EPTESETKAE IDRFVAALLA IREEIRAVEE GEIAAGDSPL RHAPHTVEDL 900
VADWDRKYPR EQGCFPPGSF RVDKYWPPVG RVDNAWGDRN LVCTCPPVES 950
YSIAAQ 956
Length:956
Mass (Da):103,072
Last modified:April 3, 2007 - v1
Checksum:i4671F169C036BEF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000577 Genomic DNA. Translation: ABN75981.1.
RefSeqiWP_011840655.1. NC_009049.1.
YP_001042753.1. NC_009049.1.

Genome annotation databases

EnsemblBacteriaiABN75981; ABN75981; Rsph17029_0870.
GeneIDi4896994.
KEGGirsh:Rsph17029_0870.
PATRICi23169434. VBIRhoSph114483_1029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000577 Genomic DNA. Translation: ABN75981.1 .
RefSeqi WP_011840655.1. NC_009049.1.
YP_001042753.1. NC_009049.1.

3D structure databases

ProteinModelPortali A3PI15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349101.Rsph17029_0870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN75981 ; ABN75981 ; Rsph17029_0870 .
GeneIDi 4896994.
KEGGi rsh:Rsph17029_0870.
PATRICi 23169434. VBIRhoSph114483_1029.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RSPH349101:GHC8-887-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17029 / ATH 2.4.9.

Entry informationi

Entry nameiGCSP_RHOS1
AccessioniPrimary (citable) accession number: A3PI15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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