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A3PI00 (BETB_RHOS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:Rsph17029_0855
OrganismRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) [Complete proteome] [HAMAP]
Taxonomic identifier349101 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter ›

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000047054

Regions

Nucleotide binding227 – 2326NAD By similarity

Sites

Active site2491 By similarity
Active site2831 By similarity

Sequences

Sequence LengthMass (Da)Tools
A3PI00 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: BBDBC8A55CB1AA92

FASTA48350,780
        10         20         30         40         50         60 
MRAQPAASHF VDGRPLEDET GAPIPVIYPA TGEEIARLHE ATPAVIEAAL ASGARAQAAW 

        70         80         90        100        110        120 
AAMRPVERAR ILRRASDLIR ARNEELSLLE TLDTGKPLQE TLVADWASGA DALEFFAGLA 

       130        140        150        160        170        180 
PAVTGETVPL GQDFVYTIRE PLGLCVGIGA WNYPSQIACW KAAPALALGN AMVFKPSEVT 

       190        200        210        220        230        240 
PLGALKLAEI LIEAGLPPGL FNVVQGRGAV GAALVTDSRV AKVSLTGSVP TGRRVYAAAA 

       250        260        270        280        290        300 
EGVRHVTMEL GGKSPLIVFD DADLESAIGA AMLGNFYSAG QICSNGTRVF VQKGIKEAFL 

       310        320        330        340        350        360 
ARLAERADAI RMGDPLDPEV QMGPLVSQAQ LEKVLAYIEK ARAEGGRLVC GGEASVSPGC 

       370        380        390        400        410        420 
YVQPTVFADV TDAMTLAREE VFGPVMAVLD FETEEEAIAR ANATDFGLAA GVFTADLTRA 

       430        440        450        460        470        480 
HRVVAQLQAG TCWINAYNLT PVEAPFGGVK LSGVGRENGR AAVEHYTQVK SVYVGMGPVD 


APY

« Hide

References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17029 / ATH 2.4.9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000577 Genomic DNA. Translation: ABN75966.1.
RefSeqYP_001042738.1. NC_009049.1.

3D structure databases

ProteinModelPortalA3PI00.
ModBaseSearch...

Protein-protein interaction databases

STRING349101.Rsph17029_0855.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN75966; ABN75966; Rsph17029_0855.
GeneID4897794.
KEGGrsh:Rsph17029_0855.
PATRIC23169398. VBIRhoSph114483_1011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAPAASHFV.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycRSPH349101:GHC8-1999-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_RHOS1
AccessionPrimary (citable) accession number: A3PI00
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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