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A3PHX4 (A3PHX4_RHOS1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase PIRNR PIRNR000099
Short name=HDH PIRNR PIRNR000099
EC=1.1.1.23 PIRNR PIRNR000099
Gene names
Ordered Locus Names:Rsph17029_0829
OrganismRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) [Complete proteome] [HAMAP]
Taxonomic identifier349101 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. PIRNR PIRNR000099 SAAS SAAS001692

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. PIRNR PIRNR000099 SAAS SAAS001692

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS001692

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. PIRNR PIRNR000099 SAAS SAAS001692

Sequence similarities

Belongs to the histidinol dehydrogenase family. PIRNR PIRNR000099 RuleBase RU004175

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3341Proton acceptor By similarity PIRSR PIRSR000099-1
Active site3351Proton acceptor By similarity PIRSR PIRSR000099-1

Sequences

Sequence LengthMass (Da)Tools
A3PHX4 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: EA6DFB2C3E4BFD42

FASTA44146,897
        10         20         30         40         50         60 
MVQVNFQVLA ELDAAGRAAL LRRSETDLSM FLEKVGPILE AVRTEGDAAL VRFGRELDRA 

        70         80         90        100        110        120 
KGLTREGLKV TEAEFDEAFG LVEPEIVEAI RFAIGNIRTF HEEQAPEPMW LKELRPGAFA 

       130        140        150        160        170        180 
GDRFTPIRSV ALYVPRGKGS FPSVTMMTSV PAVVAKVPQI AIFTPPAPDG KVDAATLVAA 

       190        200        210        220        230        240 
RLAGVETVYK VGGAQAVAAA AYGTDTVTPA LKIVGPGSPW VVAAKRLLAG VIDPGLPAGP 

       250        260        270        280        290        300 
SESIILADET VHGGLAALDL LIEAEHGPDS SAWLVTHSRQ VAEEALAALP SHWAAMTPQR 

       310        320        330        340        350        360 
VDFSQAVLCG RAGGIVLTGS AEESHAFVND YAPEHLQILS EKPFEHLGRI TEAAEVLMGP 

       370        380        390        400        410        420 
HTPITIANFC LGPNAVLPTS RGARTWGPLS VHDFLRRSSV GYVTAPAYPE LAEVAKRLAE 

       430        440 
YEGFSSHGNA VGPMRDAYLK R

« Hide

References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000577 Genomic DNA. Translation: ABN75940.1.
RefSeqYP_001042712.1. NC_009049.1.

3D structure databases

ProteinModelPortalA3PHX4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3PHX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4896765.
GenomeReviewsGene locus Rsph17029_0829 in contig CP000577_GR.
KEGGrsh:Rsph17029_0829.
PATRIC23169338. VBIRhoSph114483_0982.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHBG329596.
OMAKIVGPGS.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycRSPH349101:RSPH17029_0829-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA3PHX4_RHOS1
AccessionPrimary (citable) accession number: A3PHX4
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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