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A3PH01

- GCH4_RHOS1

UniProt

A3PH01 - GCH4_RHOS1

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei218 – 2181May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciRSPH349101:GHC8-512-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Rsph17029_0501
OrganismiRhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Taxonomic identifieri349101 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002606: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359GTP cyclohydrolase FolE2PRO_0000292756Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349101.Rsph17029_0501.

Structurei

3D structure databases

ProteinModelPortaliA3PH01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3PH01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNILTPVAER LPSREEAEEA LAVLRRWATH TPASDVAALA PEAPALVYPD
60 70 80 90 100
LSRAYPRTFT VDEAYKASLP DLQNGPASLI VGAKAVIQHV GISNFRLPIR
110 120 130 140 150
YHTRDNGDLQ LETSVTGTVS LEAEKKGINM SRIMRSFYAH AEQAFSFEVI
160 170 180 190 200
ERALEDYKRD LESFDARIQM RFSFPVKVPS LRSGLTGWQY YDIALELVDR
210 220 230 240 250
GGVRKEIMHL DFVYSSTCPC SLELSEHARR ERGQLATPHS QRSVARISVE
260 270 280 290 300
VRQGKCLWFE DLLDLVRSAV PTETQVMVKR EDEQAFAELN AANPIFVEDA
310 320 330 340 350
ARSFCQALQS DPRIGDFRVV ASHQESLHSH DAVSVLTEGP TFAAESLDPR

LFSSLYHVG
Length:359
Mass (Da):40,175
Last modified:April 3, 2007 - v1
Checksum:iFFD98B7D831BBBE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN75617.1.
RefSeqiYP_001042389.1. NC_009049.1.

Genome annotation databases

EnsemblBacteriaiABN75617; ABN75617; Rsph17029_0501.
GeneIDi4897468.
KEGGirsh:Rsph17029_0501.
PATRICi23168631. VBIRhoSph114483_0634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000577 Genomic DNA. Translation: ABN75617.1 .
RefSeqi YP_001042389.1. NC_009049.1.

3D structure databases

ProteinModelPortali A3PH01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349101.Rsph17029_0501.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN75617 ; ABN75617 ; Rsph17029_0501 .
GeneIDi 4897468.
KEGGi rsh:Rsph17029_0501.
PATRICi 23168631. VBIRhoSph114483_0634.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci RSPH349101:GHC8-512-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17029 / ATH 2.4.9.

Entry informationi

Entry nameiGCH4_RHOS1
AccessioniPrimary (citable) accession number: A3PH01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 3, 2007
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3