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Protein

Argininosuccinate synthase

Gene

argG

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei89CitrullineUniRule annotation1
Binding sitei119ATP; via amide nitrogenUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei125AspartateUniRule annotation1
Binding sitei125CitrullineUniRule annotation1
Binding sitei126AspartateUniRule annotation1
Binding sitei129CitrullineUniRule annotation1
Binding sitei177CitrullineUniRule annotation1
Binding sitei186CitrullineUniRule annotation1
Binding sitei262CitrullineUniRule annotation1
Binding sitei274CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167546:G1G8B-1827-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:P9301_18981
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000004171 – 404Argininosuccinate synthaseAdd BLAST404

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi167546.P9301_18981

Structurei

3D structure databases

ProteinModelPortaliA3PFJ6
SMRiA3PFJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A3PFJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQVKKVVLA YSGGVDTSVC IPYLKKEYGV SEVVTFVADL GQGEDLELIR
60 70 80 90 100
QKALNSGASQ SIVGNLVNSF VERYAFPAIR ANALYLDKYP LSTALARPLI
110 120 130 140 150
AENLVNIARE ISADAVAHGC TGKGNDQVRF DLAINALGPD LKIITPAREW
160 170 180 190 200
NMSREEAIEY GEKFGIPAPV SKKSPYSIDV NLLGRSIEAG ILEDPMKEAP
210 220 230 240 250
EDIFAMTSSI ENSPDSPQEV EIIFKNGFPV GINDESLTPV EIIKKANVLA
260 270 280 290 300
GEHGFGRIDM IEDRVVGIKS REIYETPGLL LLIKAHKELE SITLNPDVVD
310 320 330 340 350
FKGIVEKKWG QLVYQGFWFG PLKDSLDSFI SSTQTAVNGR VKIRLHKGNA
360 370 380 390 400
IVIGRMSENN SLYREDLATY SEEDVFNHSL AEGFIYMWGM SNKIWAELNS

KTKD
Length:404
Mass (Da):44,621
Last modified:April 3, 2007 - v1
Checksum:i6CB0CBC4AB40B722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA Translation: ABO18521.1
RefSeqiWP_011863802.1, NC_009091.1

Genome annotation databases

EnsemblBacteriaiABO18521; ABO18521; P9301_18981
GeneIDi4912515
KEGGipmg:P9301_18981

Similar proteinsi

Entry informationi

Entry nameiASSY_PROM0
AccessioniPrimary (citable) accession number: A3PFJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health