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A3PF80

- PANCY_PROM0

UniProt

A3PF80 - PANCY_PROM0

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
    Displays a CMP kinase activity.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
    ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361Proton donorUniRule annotation
    Binding sitei61 – 611Beta-alanineUniRule annotation
    Binding sitei61 – 611PantoateUniRule annotation
    Binding sitei156 – 1561PantoateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 368ATPUniRule annotation
    Nucleotide bindingi150 – 1534ATPUniRule annotation
    Nucleotide bindingi187 – 1904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR167546:GH1Y-1831-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
    Including the following 2 domains:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Cytidylate kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
    Short name:
    CKUniRule annotation
    Alternative name(s):
    Cytidine monophosphate kinaseUniRule annotation
    Short name:
    CMP kinaseUniRule annotation
    Gene namesi
    Name:panC/cmkUniRule annotation
    Ordered Locus Names:P9301_17821
    OrganismiProchlorococcus marinus (strain MIT 9301)
    Taxonomic identifieri167546 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001430: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Bifunctional pantoate ligase/cytidylate kinasePRO_0000333297Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167546.P9301_17821.

    Structurei

    3D structure databases

    ProteinModelPortaliA3PF80.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 276276Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni277 – 510234Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3PF80-1 [UniParc]FASTAAdd to Basket

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    MKKVIIRKTE EIENWRRNIN SEINFIPTMG NLHDGHIKLI STAKNDNSNV    50
    NLVSIFINPL QFDNKLDLEN YPQTIDNDIK ISFSNGADAI FIPSYEDIYP 100
    PNNKNIKFLK APKELSSALC GLNRIGHFDG VCTVVYRLLN LIKPKNLYLG 150
    EKDWQQLLIL KNLVLRKNLN VAIRSIPTQR DFDGIPLSSR NVHLSKNERK 200
    LISFFSSELL EAKKIFQQDK KINLNQIIKK LSAKKISVEY LEHLHPHTLQ 250
    KARPEDNISL LAGAIRCGET RLIDHVFLMK RRPIIAIDGP AGSGKSTVTK 300
    LIAKKLNLLY LDTGAMYRAL SWLIIKESVD YKIEKKLQNI LKDISIFFKS 350
    NTNSHQDVYV NNYCVTKEIR SQKISSIVSK ISSIKEVRKF LVAEQRKIGE 400
    SGGLVAEGRD IGTTVFPHAE LKIFLTASID ERAKRRKYDK NSKDSQEIDL 450
    YTLKELIKKR DFEDSNREIS PLIKANDAIE IITDGYTIDE VVDKIIDLYN 500
    DRIPKETEIK 510
    Length:510
    Mass (Da):58,445
    Last modified:April 3, 2007 - v1
    Checksum:iE82DF93842EDC030
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000576 Genomic DNA. Translation: ABO18405.1.
    RefSeqiWP_011863693.1. NC_009091.1.
    YP_001092006.1. NC_009091.1.

    Genome annotation databases

    EnsemblBacteriaiABO18405; ABO18405; P9301_17821.
    GeneIDi4911848.
    KEGGipmg:P9301_17821.
    PATRICi22997073. VBIProMar103344_1706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000576 Genomic DNA. Translation: ABO18405.1 .
    RefSeqi WP_011863693.1. NC_009091.1.
    YP_001092006.1. NC_009091.1.

    3D structure databases

    ProteinModelPortali A3PF80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167546.P9301_17821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO18405 ; ABO18405 ; P9301_17821 .
    GeneIDi 4911848.
    KEGGi pmg:P9301_17821.
    PATRICi 22997073. VBIProMar103344_1706.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci PMAR167546:GH1Y-1831-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9301.

    Entry informationi

    Entry nameiPANCY_PROM0
    AccessioniPrimary (citable) accession number: A3PF80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3