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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional pantoate ligase/cytidylate kinase (panC/cmk)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei156PantoateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 36ATPUniRule annotation8
Nucleotide bindingi150 – 153ATPUniRule annotation4
Nucleotide bindingi187 – 190ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Ligase, Multifunctional enzyme, Transferase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167546:G1G8B-1706-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
Including the following 2 domains:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:panC/cmkUniRule annotation
Ordered Locus Names:P9301_17821
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332971 – 510Bifunctional pantoate ligase/cytidylate kinaseAdd BLAST510

Interactioni

Protein-protein interaction databases

STRINGi167546.P9301_17821

Structurei

3D structure databases

ProteinModelPortaliA3PF80
SMRiA3PF80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 276Pantoate--beta-alanine ligaseAdd BLAST276
Regioni277 – 510Cytidylate kinaseUniRule annotationAdd BLAST234

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT Bacteria
COG0283 LUCA
COG0414 LUCA
HOGENOMiHOG000233355
KOiK13799
OMAiLGEKDWQ
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00238 Cytidyl_kinase_type1, 1 hit
MF_00158 PanC, 1 hit
MF_01349 PanCY, 1 hit
InterProiView protein in InterPro
IPR003136 Cytidylate_kin
IPR011994 Cytidylate_kinase_dom
IPR027417 P-loop_NTPase
IPR003721 Pantoate_ligase
IPR024894 Pantoate_ligase/cytidylate_kin
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF02224 Cytidylate_kin, 1 hit
PF02569 Pantoate_ligase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00017 cmk, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

A3PF80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVIIRKTE EIENWRRNIN SEINFIPTMG NLHDGHIKLI STAKNDNSNV
60 70 80 90 100
NLVSIFINPL QFDNKLDLEN YPQTIDNDIK ISFSNGADAI FIPSYEDIYP
110 120 130 140 150
PNNKNIKFLK APKELSSALC GLNRIGHFDG VCTVVYRLLN LIKPKNLYLG
160 170 180 190 200
EKDWQQLLIL KNLVLRKNLN VAIRSIPTQR DFDGIPLSSR NVHLSKNERK
210 220 230 240 250
LISFFSSELL EAKKIFQQDK KINLNQIIKK LSAKKISVEY LEHLHPHTLQ
260 270 280 290 300
KARPEDNISL LAGAIRCGET RLIDHVFLMK RRPIIAIDGP AGSGKSTVTK
310 320 330 340 350
LIAKKLNLLY LDTGAMYRAL SWLIIKESVD YKIEKKLQNI LKDISIFFKS
360 370 380 390 400
NTNSHQDVYV NNYCVTKEIR SQKISSIVSK ISSIKEVRKF LVAEQRKIGE
410 420 430 440 450
SGGLVAEGRD IGTTVFPHAE LKIFLTASID ERAKRRKYDK NSKDSQEIDL
460 470 480 490 500
YTLKELIKKR DFEDSNREIS PLIKANDAIE IITDGYTIDE VVDKIIDLYN
510
DRIPKETEIK
Length:510
Mass (Da):58,445
Last modified:April 3, 2007 - v1
Checksum:iE82DF93842EDC030
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA Translation: ABO18405.1
RefSeqiWP_011863693.1, NC_009091.1

Genome annotation databases

EnsemblBacteriaiABO18405; ABO18405; P9301_17821
GeneIDi4911848
KEGGipmg:P9301_17821

Similar proteinsi

Entry informationi

Entry nameiPANCY_PROM0
AccessioniPrimary (citable) accession number: A3PF80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health