A3PF64 (CAPP_PROM0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoenolpyruvate carboxylase
Short name=PEPC
Short name=PEPCase
EC=4.1.1.31

Gene names

Name:	ppc
Ordered Locus Names:	P9301_17661

Organism

Prochlorococcus marinus (strain MIT 9301) [Complete proteome] [HAMAP]

Taxonomic identifier

167546 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus › Prochlorococcus marinus

Protein attributes

Sequence length	989 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595
Catalytic activity	Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595
Cofactor	Magnesium By similarity. HAMAP-Rule MF_00595
Sequence similarities	Belongs to the PEPCase type 1 family.

Ontologies

Keywords
Biological process	Carbon dioxide fixation
Ligand	Magnesium
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbon fixation Inferred from electronic annotation. Source: HAMAP oxaloacetate metabolic process Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoenolpyruvate carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 989	989	Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595		PRO_1000025570
Sites
	Active site	175	1	By similarity
	Active site	630	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3PF64 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 14EA9E867FE45A67	FASTA	989	114,214
	10 20 30 40 50 60 MESFRQIKNN NVDLISNNDP LDKNRLLIED LWESVLREEC PDDQAERLIQ LKELSYSKQI 70 80 90 100 110 120 DGNSSKTFKN EIVDIVNSMD LAESIAAARA FSLYFQLVNI LEQRVEEDRY IQSFTNKDVQ 130 140 150 160 170 180 KSPDNLDPFA PALARQNAPV TFRELFYRLR KLNVPPGKLE ELLQEMDIRL VFTAHPTEIV 190 200 210 220 230 240 RHTIRHKQTR VANLLKKIQI EQFLTKDEKI SLKTQLKEEV RLWWRTDELH QFKPSVLDEV 250 260 270 280 290 300 DYSLHYFQQV LFNAMPQLRG RITEALTENY PDVQLPPESF CNFGSWVGSD RDGNPSVTPD 310 320 330 340 350 360 ITWRTACYQR QLMLDRYIVA TSNLRDQLSV SMQWSQVSSS LLESLETDRV KFPEIYEARA 370 380 390 400 410 420 TRYRSEPYRL KLSYILEKLR LTQERNNLLA DSGWKFDFEG EIDNKNIDKV ENLYYKSVNE 430 440 450 460 470 480 FTYDLELIKN SLISTDLTCD SVNNLLTQVH IFGFSLASLD IRQESTRHSD AIQELTNYLD 490 500 510 520 530 540 LSVQYDQMSE EEKIKWLIDE LNTKRPLIPS DVNWTKTTEE TFSVFKMVKR LQQEFGSRIC 550 560 570 580 590 600 HSYVISMSHS ASDLLEVLLL AKEMGLLDQD SQKSKLLVVP LFETVEDLQR APEVMEKLFK 610 620 630 640 650 660 LDFYKSLLPK VGESFKPLQE LMLGYSDSNK DSGFVSSNWE IHRAQIALQN LSSRNNILLR 670 680 690 700 710 720 LFHGRGGSVG RGGGPAYQAI LAQPSGTLKG RIKITEQGEV LASKYSLPEL ALYNLETVTT 730 740 750 760 770 780 AVIQNSLVNS RLDATPEWNQ LMSRLAETSR SHYRKLVHEN PDLLNFFQEV TPIEEISKLQ 790 800 810 820 830 840 ISSRPARRKK GAKDLSSLRA IPWVFGWTQS RFLLPSWFGV GTALSAELNS DPQQIELLRV 850 860 870 880 890 900 LHQRWPFFRM LISKVEMTLS KVDLEVARYY VDTLGSKENK DSFDNIFEVI SKEYNLTKSL 910 920 930 940 950 960 ILEITGKNKL LESDRDLKSS VSLRNKTIIP LGFLQVSLLR RLRDQTRQPP ISEFLIDKDE 970 980 SRRAYSRSEL LRGALLTING IAAGMRNTG

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000576 Genomic DNA. Translation: ABO18389.1.
RefSeq	YP_001091990.1. NC_009091.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	167546.P9301_17661.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABO18389; ABO18389; P9301_17661.
GeneID	4911812.
KEGG	pmg:P9301_17661.
PATRIC	22997043. VBIProMar103344_1692.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2352.
HOGENOM	HOG000238647.
KO	K01595.
OMA	AIPWVFG.
ProtClustDB	PRK00009.
Enzyme and pathway databases
BioCyc	PMAR167546:GH1Y-1814-MONOMER.
Family and domain databases
HAMAP	MF_00595. PEPcase_type1.
InterPro	IPR021135. PEP_COase. IPR018129. PEP_COase_AS. IPR022805. PEP_COase_bac/pln-type. IPR015813. Pyrv/PenolPyrv_Kinase-like_dom. [Graphical view]
Pfam	PF00311. PEPcase. 1 hit. [Graphical view]
PRINTS	PR00150. PEPCARBXLASE.
SUPFAM	SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
PROSITE	PS00781. PEPCASE_1. 1 hit. PS00393. PEPCASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPP_PROM0

Accession

Primary (citable) accession number: A3PF64

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	May 29, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program