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Protein

Adenylosuccinate lyase

Gene

purB

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPMAR167546:G1G8B-1577-MONOMER
UniPathwayiUPA00074; UER00132
UPA00075; UER00336

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purBImported
Ordered Locus Names:P9301_16551Imported
OrganismiProchlorococcus marinus (strain MIT 9301)Imported
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi167546.P9301_16551

Structurei

3D structure databases

ProteinModelPortaliA3PEV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini349 – 430ADSL_CInterPro annotationAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili45 – 65Sequence analysisAdd BLAST21
Coiled coili103 – 130Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C83 Bacteria
COG0015 LUCA
HOGENOMiHOG000033912
KOiK01756
OMAiASSCEKI
OrthoDBiPOG091H0168

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR019468 AdenyloSucc_lyase_C
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR004769 Pur_lyase
PfamiView protein in Pfam
PF10397 ADSL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SMARTiView protein in SMART
SM00998 ADSL_C, 1 hit
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00928 purB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A3PEV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIERYTLPEM GKIWTDSAKF QSWLKVEIAA CEANFSLGKI PENAMKEIRS
60 70 80 90 100
NAKFDESRIA EIEKEVKHDV IAFLTSVNEF VGDSGRYIHV GMTSSDVLDT
110 120 130 140 150
GLSLQLKDSC ELLSEEIENL ENEVRLLARK HKNTLMIGRS HAIHGEPISF
160 170 180 190 200
GFKLAGWLAE IIRNKKRLLT LKESVAIGQI SGAMGTYANT NPKVEQITCD
210 220 230 240 250
LLGLKPDTAS TQVISRDRHA EYVQTIALVG ASLDRFATEI RNLQRTDVLE
260 270 280 290 300
VEEGFTKGQK GSSAMPHKRN PIRSERVSGL ARILRSYVLT ALDNVPLWHE
310 320 330 340 350
RDISHSSNER IMLPDVSICL HFMLREMKDI VSNLEVYPKN MLKNLNIYGG
360 370 380 390 400
VIFSQKVLLL LVEKGLSREK AYSLVQKNAH QAWNTENGNF KQNIERDNEI
410 420 430
MDFIDQSDLE ECFNPSIHLN NLSVIWEKLG I
Length:431
Mass (Da):48,796
Last modified:April 3, 2007 - v1
Checksum:i694CE3E34CBC6AEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA Translation: ABO18278.1
RefSeqiWP_011863575.1, NC_009091.1

Genome annotation databases

EnsemblBacteriaiABO18278; ABO18278; P9301_16551
GeneIDi4911004
KEGGipmg:P9301_16551

Similar proteinsi

Entry informationi

Entry nameiA3PEV3_PROM0
AccessioniPrimary (citable) accession number: A3PEV3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health