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A3PCW8

- SYL_PROM0

UniProt

A3PCW8 - SYL_PROM0

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR167546:GH1Y-996-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:P9301_09701
    OrganismiProchlorococcus marinus (strain MIT 9301)
    Taxonomic identifieri167546 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001430: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 856856Leucine--tRNA ligasePRO_1000009392Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167546.P9301_09701.

    Structurei

    3D structure databases

    ProteinModelPortaliA3PCW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi53 – 6311"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVHRQSWP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3PCW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISPDQQYET DTNLYNPSEI EKKWQSIWTE NNLYKTDELT DNSDKFYALS    50
    MFPYPSGNLH MGHVRNYVIT DLIARFQRFK GKSVLHPMGW DAFGLPAENA 100
    AIERGISPSV WTKKNISHMK SQLKLLGLSV DWDREFATCD ENYYVWTQYL 150
    FLELYKAGLV YQKESEVNWD PIDNTVLANE QVDSEGKSWR SGAIVEKKLL 200
    KQWFLRITNY ADELLKDLEK LDNWPERVKI MQDNWIGKSI GTNINFNINT 250
    HPEKKLTVFT TRPDTLFGVT YLAISVNHSL IKNISDQETI QHIENLKKYL 300
    KKNKNNELEK IGIKTSLIAI NPVNSEPIPI WVASYVLDEY GTGAVMGVPA 350
    HDLRDFEFAK KNNIDIKQVI IKDKSEQNKE LDEAYVENGY LINSNQYDGV 400
    ANTIAKLKIS EEGVNNRWAE NKTQYRLRDW LISRQRYWGC PIPIVNCKKC 450
    GSVPLNQSEL PVALPKDIDI SANKINALGD NKNWVNTTCP KCGIAAKKET 500
    DTMDTFMCSS WYFLRYPSSK CPNKPFEKIE INKWLPVDQY VGGVEHAILH 550
    LLYARFFTKA LRDNQLFEID EPFKKLLTQG MVQAAAYKNN KTGKYVSPSD 600
    INDLSNPTDP IDNTKLEILF EKMSKSKYNG IDPESVIKKY GADTARMFIL 650
    FKAPPEKDLE WGDTDVEGQF RFLSRIWKLY INCAKNVNIK SNSYPDKEKS 700
    LIKSMNIAIK EISNDILNNQ FNTAISELMK FYNSLSNSIN DVNNNLKIDA 750
    LKTFCILLAP FAPHIAEEIW HLIGFKKSVH LEHWPSFNAE ALKEDSYELV 800
    IQVNGKVREK VNINHDMNED QIKELTLKRP NILKWTKDKE IRKIIIVKGK 850
    IMNIVV 856
    Length:856
    Mass (Da):98,780
    Last modified:April 3, 2007 - v1
    Checksum:iCA4C08EB051D04E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000576 Genomic DNA. Translation: ABO17593.1.
    RefSeqiYP_001091194.1. NC_009091.1.

    Genome annotation databases

    EnsemblBacteriaiABO17593; ABO17593; P9301_09701.
    GeneIDi4911693.
    KEGGipmg:P9301_09701.
    PATRICi22995515. VBIProMar103344_0943.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000576 Genomic DNA. Translation: ABO17593.1 .
    RefSeqi YP_001091194.1. NC_009091.1.

    3D structure databases

    ProteinModelPortali A3PCW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167546.P9301_09701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO17593 ; ABO17593 ; P9301_09701 .
    GeneIDi 4911693.
    KEGGi pmg:P9301_09701.
    PATRICi 22995515. VBIProMar103344_0943.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VHRQSWP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PMAR167546:GH1Y-996-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9301.

    Entry informationi

    Entry nameiSYL_PROM0
    AccessioniPrimary (citable) accession number: A3PCW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3