A3PCW5 (ARGC_PROM0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	P9301_09671

Organism

Prochlorococcus marinus (strain MIT 9301) [Complete proteome] [HAMAP]

Taxonomic identifier

167546 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011031
Sites
	Active site	154	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3PCW5 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 80F115AD0BD8716A	FASTA	351	38,736
	10 20 30 40 50 60 MNVAIVGATG YGGIQAVNLL KKNKNYKISF LGGNKTSGLK WNDNFPFIYL DNDPYIEEIS 70 80 90 100 110 120 VDNISKNADV ALLCLPNGLS STLTRKLLDK GLKVIDLSAD YRYKSLDEWK KVYSKEAAIY 130 140 150 160 170 180 KRNDDDLCKE AVYGLPEINK EAISKGRLIA CPGCYPTSAL IPLAPYLSQG IIENEGIVID 190 200 210 220 230 240 SKSGTSGGGR EPNQKLLLSE CGEGLSAYGL INHRHTSEIE QVASLISGTK IELLFTPHLV 250 260 270 280 290 300 PISRGMHSTI YGRLRDPGLT SDDCRILLDN YYRNFKNIKV LPVDTFPSTK WVKNTNQILL 310 320 330 340 350 SVKVDNRNGR IIILSVIDNL LKGQTGQAIQ NLNIMSGFSM DEGLDLTNNF P

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000576 Genomic DNA. Translation: ABO17590.1.
RefSeq	YP_001091191.1. NC_009091.1.
3D structure databases
ProteinModelPortal	A3PCW5.
ModBase	Search...
Protein-protein interaction databases
STRING	A3PCW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4911690.
GenomeReviews	Gene locus P9301_09671 in contig CP000576_GR.
KEGG	pmg:P9301_09671.
PATRIC	22995509. VBIProMar103344_0940.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	A3PCW5.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	PMAR167546:P9301ORF_0986-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_PROM0

Accession

Primary (citable) accession number: A3PCW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program