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A3PCQ0 (UPPP_PROM0) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:P9301_09021
OrganismProchlorococcus marinus (strain MIT 9301) [Complete proteome] [HAMAP]
Taxonomic identifier167546 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290746

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A3PCQ0 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 47905B9C4766CAE8

FASTA26629,550
        10         20         30         40         50         60 
MEYLKFVLYG LIQGLTEFIP VSSTAHLKVI SLFLGIDDPG ASLSATIQLG SVIAIAYYFR 

        70         80         90        100        110        120 
NDIFNFRSQS SKKFLEYLFH ERLLRSIFIG TIPIVLLGGS IKIFIPSFFE NVLRSNLSIA 

       130        140        150        160        170        180 
LVSFLMAFFM YLADSSKRGS INIKNHNFSN SFLIGIFQAF AIFPGVSRSG VTISSALISG 

       190        200        210        220        230        240 
WERGDAAKFS FLLGMPAISL AAIVEFVSSF NDFFSLGFFP LFVGLITTFL SSLLAIDFLL 

       250        260 
KYFSSNGLKI FIIYRVIFGV VILLNL 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000576 Genomic DNA. Translation: ABO17525.1.
RefSeqYP_001091126.1. NC_009091.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167546.P9301_09021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO17525; ABO17525; P9301_09021.
GeneID4912329.
KEGGpmg:P9301_09021.
PATRIC22995373. VBIProMar103344_0874.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAEYLFHER.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycPMAR167546:GH1Y-926-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_PROM0
AccessionPrimary (citable) accession number: A3PCQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families