A3PCJ6 (A3PCJ6_PROM0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523
EC=2.3.1.- HAMAP MF_00523

Gene names

Name:	lpxD HAMAP MF_00523
Ordered Locus Names:	P9301_08481

Organism

Prochlorococcus marinus (strain MIT 9301) [Complete proteome] [HAMAP] EMBL ABO17471.1

Taxonomic identifier

167546 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523 UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. SAAS SAAS020573
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523 Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. SAAS SAAS020573
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily. HAMAP MF_00523

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00523 SAAS SAAS020573 Lipid synthesis
Domain	Repeat HAMAP MF_00523 SAAS SAAS020573
Molecular function	Acyltransferase HAMAP MF_00523 SAAS SAAS020573 EMBL ABO17471.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3PCJ6 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: BD49348B6CD7A659	FASTA	344	36,980
	10 20 30 40 50 60 MLLSDLVDLI KKGNSNFISA NIFEDLNIDD AASLDAAVKH QISFLEENNI LKEKLDQTKA 70 80 90 100 110 120 SAIITTNNDE IVSALKKLNI SNIIVKNPRI AFAEVLDYLY KTINFKPGIH ASAVIDKTAI 130 140 150 160 170 180 IGADCHIGPN VYIGENTIIG DNNHILPGSS ILGNVQIGNN NIIHPNCVIY ENTTLKNNCV 190 200 210 220 230 240 INSNSVIGSE GFGFIPENGK WVKMPQKGGV KIMSFVEIGT NCCIDRPAVG FTFIDEGTKL 250 260 270 280 290 300 DNLIQIGHGV KIGKNCAFAA QVGIAGGANI GDGVILAGQV GVNNRVKVGN NVIASSKCGI 310 320 330 340 HCDIEDGKVI SGFPAMENKS WLRSSSIFKK LPELAKKLRQ LDKQ

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000576 Genomic DNA. Translation: ABO17471.1.
RefSeq	YP_001091072.1. NC_009091.1.
3D structure databases
ProteinModelPortal	A3PCJ6.
ModBase	Search...
Protein-protein interaction databases
STRING	A3PCJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4911204.
GenomeReviews	Gene locus P9301_08481 in contig CP000576_GR.
KEGG	pmg:P9301_08481.
PATRIC	22995269. VBIProMar103344_0822.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	CFVGKNT.
PhylomeDB	A3PCJ6.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	PMAR167546:P9301ORF_0864-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3PCJ6_PROM0

Accession

Primary (citable) accession number: A3PCJ6

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)