A3PBU3 (A3PBU3_PROM0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydroorotase EMBL ABO17218.1
EC=3.5.2.3 EMBL ABO17218.1

Gene names

Ordered Locus Names:

P9301_05951

Organism

Prochlorococcus marinus (strain MIT 9301) [Complete proteome] [HAMAP] EMBL ABO17218.1

Taxonomic identifier

167546 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. SAAS SAAS004721
Cofactor	Binds 2 zinc ions per subunit By similarity. SAAS SAAS004721
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. SAAS SAAS004721
Subunit structure	Homodimer By similarity. SAAS SAAS004721

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS004721
Ligand	Metal-binding SAAS SAAS004721 Zinc SAAS SAAS004721
Molecular function	Hydrolase SAAS SAAS004721 EMBL ABO17218.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3PBU3 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 1816077F7079A8CF	FASTA	349	39,638
	10 20 30 40 50 60 MKTLTIIKPD DWHLHLREGL VLKNIIHFTS EYFGRAIVMP NTKVPITSIK SAISYKKSII 70 80 90 100 110 120 EALPESSKFK PLMTMYLTDE TDKGELINGF KNNVFFAAKL YPANATTNSS HGVRKIENLY 130 140 150 160 170 180 KIFESMQDSG MPLLIHGEVT DSEVDVFDRE EVFIDKELSQ ITKRFPKLKI VLEHITTSYA 190 200 210 220 230 240 VNFVKENNIG ATITPHHLHI NRNAMFFGGL NSDFYCLPVA KRENNRLALR KAATSGEKCF 250 260 270 280 290 300 FLGTDSAPHL RKWKAFCGCA GIFNSPVAIE SYLTVFEEED ALDNFEKFAS LNGPNFYNVP 310 320 330 340 PNKEKLKLVS RPNKIKEFID VIQEKNTVGQ IKPFHAGETL QWQVEGKLI

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000576 Genomic DNA. Translation: ABO17218.1.
RefSeq	YP_001090819.1. NC_009091.1.
3D structure databases
ProteinModelPortal	A3PBU3.
ModBase	Search...
Protein-protein interaction databases
STRING	A3PBU3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4911368.
GenomeReviews	Gene locus P9301_05951 in contig CP000576_GR.
KEGG	pmg:P9301_05951.
PATRIC	22994783. VBIProMar103344_0581.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0418.
HOGENOM	HBG628648.
OMA	CLPVAKR.
PhylomeDB	A3PBU3.
ProtClustDB	PRK05451.
Enzyme and pathway databases
BioCyc	PMAR167546:P9301ORF_0609-MONOMER.
Family and domain databases
InterPro	IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view]
KO	K01465.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
PIRSF	PIRSF001237. DHOdimr. 1 hit.
TIGRFAMs	TIGR00856. PyrC_dimer. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A3PBU3_PROM0

Accession

Primary (citable) accession number: A3PBU3

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)