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A3PAY7

- PUR9_PROM0

UniProt

A3PAY7 - PUR9_PROM0

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, P9301_02891
Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMAR167546:GH1Y-295-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:P9301_02891
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000018925Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167546.P9301_02891.

Structurei

3D structure databases

ProteinModelPortaliA3PAY7.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCNLKGIS.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PAY7-1 [UniParc]FASTAAdd to Basket

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MSPLALVSVS DKKNIIPFCK ELIEQFNYKI LSSGGTAKHL IDAKIPVIKV    50
ADFTNSPEIL GGRVKTLHPK IHGGILAKRT DEEHKKDVET NNLELIDLVV 100
VNLYPFKKTV DQGAQWEDAI ENIDIGGPSM IRSAAKNHKD VSVLVDPSQY 150
QNFLEESKKG ELKDAYKAKL ALEAFQHTAD YDTAISNWIR KERDLQSSKY 200
IESYPLIKTL RYGENPHQKA FWYGLSNIGW NSAEQLQGKD LSYNNLLDLE 250
SALSTVLEFG YTEKDELKTD MFASVILKHN NPCGASISNS ASKAFLNALE 300
CDSVSAFGGI VAFNSNVDSD TAVHLKDIFL ECVVAPSFDE EALEILKVKK 350
NLRILKFSKD QLPKKNQNST KSIMGGLLVQ DTDDSQEKTE DWISVTNKNA 400
NNQANLDLNF AWKICKHVKS NAIVIAKDQK TIGIGAGQMN RVGAAKIALK 450
AAGSLCSDAV LASDGFFPFA DTVELAHEYG IKAIIQPGGS LRDQESIDMC 500
NLKGISMIFT QKRHFLH 517
Length:517
Mass (Da):57,214
Last modified:April 3, 2007 - v1
Checksum:iD20C7F8759A4F712
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000576 Genomic DNA. Translation: ABO16912.1.
RefSeqiWP_011862307.1. NC_009091.1.
YP_001090513.1. NC_009091.1.

Genome annotation databases

EnsemblBacteriaiABO16912; ABO16912; P9301_02891.
GeneIDi4911155.
KEGGipmg:P9301_02891.
PATRICi22994169. VBIProMar103344_0286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000576 Genomic DNA. Translation: ABO16912.1 .
RefSeqi WP_011862307.1. NC_009091.1.
YP_001090513.1. NC_009091.1.

3D structure databases

ProteinModelPortali A3PAY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167546.P9301_02891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO16912 ; ABO16912 ; P9301_02891 .
GeneIDi 4911155.
KEGGi pmg:P9301_02891.
PATRICi 22994169. VBIProMar103344_0286.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CNLKGIS.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMAR167546:GH1Y-295-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9301.

Entry informationi

Entry nameiPUR9_PROM0
AccessioniPrimary (citable) accession number: A3PAY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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