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A3PAY7

- PUR9_PROM0

UniProt

A3PAY7 - PUR9_PROM0

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPMAR167546:GH1Y-295-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:P9301_02891
    OrganismiProchlorococcus marinus (strain MIT 9301)
    Taxonomic identifieri167546 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001430: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Bifunctional purine biosynthesis protein PurHPRO_1000018925Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167546.P9301_02891.

    Structurei

    3D structure databases

    ProteinModelPortaliA3PAY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiCNLKGIS.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3PAY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPLALVSVS DKKNIIPFCK ELIEQFNYKI LSSGGTAKHL IDAKIPVIKV    50
    ADFTNSPEIL GGRVKTLHPK IHGGILAKRT DEEHKKDVET NNLELIDLVV 100
    VNLYPFKKTV DQGAQWEDAI ENIDIGGPSM IRSAAKNHKD VSVLVDPSQY 150
    QNFLEESKKG ELKDAYKAKL ALEAFQHTAD YDTAISNWIR KERDLQSSKY 200
    IESYPLIKTL RYGENPHQKA FWYGLSNIGW NSAEQLQGKD LSYNNLLDLE 250
    SALSTVLEFG YTEKDELKTD MFASVILKHN NPCGASISNS ASKAFLNALE 300
    CDSVSAFGGI VAFNSNVDSD TAVHLKDIFL ECVVAPSFDE EALEILKVKK 350
    NLRILKFSKD QLPKKNQNST KSIMGGLLVQ DTDDSQEKTE DWISVTNKNA 400
    NNQANLDLNF AWKICKHVKS NAIVIAKDQK TIGIGAGQMN RVGAAKIALK 450
    AAGSLCSDAV LASDGFFPFA DTVELAHEYG IKAIIQPGGS LRDQESIDMC 500
    NLKGISMIFT QKRHFLH 517
    Length:517
    Mass (Da):57,214
    Last modified:April 3, 2007 - v1
    Checksum:iD20C7F8759A4F712
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000576 Genomic DNA. Translation: ABO16912.1.
    RefSeqiWP_011862307.1. NC_009091.1.
    YP_001090513.1. NC_009091.1.

    Genome annotation databases

    EnsemblBacteriaiABO16912; ABO16912; P9301_02891.
    GeneIDi4911155.
    KEGGipmg:P9301_02891.
    PATRICi22994169. VBIProMar103344_0286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000576 Genomic DNA. Translation: ABO16912.1 .
    RefSeqi WP_011862307.1. NC_009091.1.
    YP_001090513.1. NC_009091.1.

    3D structure databases

    ProteinModelPortali A3PAY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167546.P9301_02891.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO16912 ; ABO16912 ; P9301_02891 .
    GeneIDi 4911155.
    KEGGi pmg:P9301_02891.
    PATRICi 22994169. VBIProMar103344_0286.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi CNLKGIS.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PMAR167546:GH1Y-295-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9301.

    Entry informationi

    Entry nameiPUR9_PROM0
    AccessioniPrimary (citable) accession number: A3PAY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3