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Protein

1,4-dihydroxy-2-naphthoyl-CoA hydrolase

Gene

P9301_01931

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.UniRule annotation

Catalytic activityi

1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA.UniRule annotation

Pathwayi: phylloquinone biosynthesis

This protein is involved in the pathway phylloquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phylloquinone biosynthesis and in Cofactor biosynthesis.

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (P9301_01931)
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciPMAR167546:G1G8B-189-MONOMER
UniPathwayiUPA00995
UPA01057; UER01033

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoyl-CoA hydrolaseUniRule annotation (EC:3.1.2.28UniRule annotation)
Short name:
DHNA-CoA hydrolaseUniRule annotation
Alternative name(s):
DHNA-CoA thioesteraseUniRule annotation
Gene namesi
Ordered Locus Names:P9301_01931
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003770191 – 1501,4-dihydroxy-2-naphthoyl-CoA hydrolaseAdd BLAST150

Interactioni

Protein-protein interaction databases

STRINGi167546.P9301_01931

Structurei

3D structure databases

ProteinModelPortaliA3PAP1
SMRiA3PAP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WGP Bacteria
COG0824 LUCA
HOGENOMiHOG000056134
KOiK12073
OMAiIVNCEAN
OrthoDBiPOG091H02B8

Family and domain databases

HAMAPiMF_02101 DHNA_CoA_hydrolase, 1 hit
InterProiView protein in InterPro
IPR022829 DHNA_CoA_hydrolase
IPR029069 HotDog_dom_sf
SUPFAMiSSF54637 SSF54637, 1 hit

Sequencei

Sequence statusi: Complete.

A3PAP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSDWLILQ KKVRFGDCDS AGVIHFHNLL KWSHEAWEES IEIYGIPCND
60 70 80 90 100
IFPDFSIRKS QIIFPIVNCE ANFNAPIKIG DLLKVKIAPH KINTHLFQVN
110 120 130 140 150
SFFIKNGNKV AEGKIIHCSL DVDSRNKIEI PDQLERWIEA SNVSTNLKEC
Length:150
Mass (Da):17,216
Last modified:April 3, 2007 - v1
Checksum:i8D43E28DDD0A73DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA Translation: ABO16816.1
RefSeqiWP_011862218.1, NC_009091.1

Genome annotation databases

EnsemblBacteriaiABO16816; ABO16816; P9301_01931
GeneIDi4912851
KEGGipmg:P9301_01931

Similar proteinsi

Entry informationi

Entry nameiDNCH_PROM0
AccessioniPrimary (citable) accession number: A3PAP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health