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Protein

NAD(P)H-quinone oxidoreductase chain 4

Gene

ndhD

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP, Plastoquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-quinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.-UniRule annotation)
Alternative name(s):
NAD(P)H dehydrogenase I, chain 4UniRule annotation
NDH-1, chain 4UniRule annotation
Gene namesi
Name:ndhDUniRule annotation
Ordered Locus Names:P9301_01691
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

Subcellular locationi

  • Cellular thylakoid membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Transmembranei41 – 61HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei141 – 161HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei217 – 237HelicalUniRule annotationAdd BLAST21
Transmembranei248 – 268HelicalUniRule annotationAdd BLAST21
Transmembranei282 – 302HelicalUniRule annotationAdd BLAST21
Transmembranei311 – 331HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei381 – 401HelicalUniRule annotationAdd BLAST21
Transmembranei422 – 442HelicalUniRule annotationAdd BLAST21
Transmembranei469 – 489HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003432371 – 531NAD(P)H-quinone oxidoreductase chain 4Add BLAST531

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi167546.P9301_01691.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8S. Bacteria.
COG1008. LUCA.
HOGENOMiHOG000100683.
KOiK05575.
OMAiTAPVHML.
OrthoDBiPOG091H09WR.

Family and domain databases

HAMAPiMF_00491. NDH1_NuoM. 1 hit.
InterProiView protein in InterPro
IPR022997. NADH_Q_OxRdtase_chain4.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
PANTHERiPTHR43507. PTHR43507. 1 hit.
PTHR43507:SF3. PTHR43507:SF3. 1 hit.
PfamiView protein in Pfam
PF00361. Proton_antipo_M. 1 hit.
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PAL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAGLSNFP WLSASILFPI GSAFVIPFFP DKGDGKEVRW FALSIALITF
60 70 80 90 100
LITVGSYING FDINNENVQL KENISWLPDL GLTWSVGADG MSMPLILLTS
110 120 130 140 150
FITALAVLAA WPVKFKPKLF FFLILVMDGG QIAVFAVQDM LLFFLTWELE
160 170 180 190 200
LIPVYLLLAI WGGKNRQYAA TKFIIYTAGS SIFILLAALA MGFYGTEIPN
210 220 230 240 250
FEFSHLAAQD FNQKFQIFCY VGLLIAFGVK LPIVPLHTWL PDAHGEATAP
260 270 280 290 300
VHMLLAGILL KMGGYALLRF NAQLLPVAHA QFAPLLIVLG VVNIIYAALT
310 320 330 340 350
SFAQRNLKRK IAYSSISHMG FVLIGIGSFS SLGTSGAMLQ MVSHGLIGAS
360 370 380 390 400
LFFLVGATYD RTKTLKLDEM SGVGQKMRIM FALWTACSLA SLALPGMSGF
410 420 430 440 450
VSELMVFTGF VTDEVYTLPF RVVMASLAAI GVILTPIYLL SMLREIFFGK
460 470 480 490 500
ENPKLIEERK LIDAEPREVY IIACLLLPII GIGLYPRLVT ESYIASINNL
510 520 530
VDRDLTAVKS AVKTNIFSGT KTNDILKAPT I
Length:531
Mass (Da):58,164
Last modified:April 3, 2007 - v1
Checksum:i9E6DD18E068E68C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA. Translation: ABO16792.1.
RefSeqiWP_011862195.1. NC_009091.1.

Genome annotation databases

EnsemblBacteriaiABO16792; ABO16792; P9301_01691.
GeneIDi4912571.
KEGGipmg:P9301_01691.

Similar proteinsi

Entry informationi

Entry nameiNU4C_PROM0
AccessioniPrimary (citable) accession number: A3PAL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: April 3, 2007
Last modified: October 25, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families