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Protein

Thymidylate kinase

Gene

tmk

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167546:G1G8B-145-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:P9301_01491
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000232451 – 212Thymidylate kinaseAdd BLAST212

Interactioni

Protein-protein interaction databases

STRINGi167546.P9301_01491

Structurei

3D structure databases

ProteinModelPortaliA3PAJ7
SMRiA3PAJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229078
KOiK00943
OMAiFLYTADH
OrthoDBiPOG091H02B9

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A3PAJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGKFIVIEG IDGCGKTTQI DELSKWLPIS GLLKKESKLI TTREPGGSLL
60 70 80 90 100
GKKLRRLILD NNENNKPSSL AELLLYSADR AEHVSKIILP ALNNNDWVIS
110 120 130 140 150
DRFSDSTLAY QGYGRNINLE IIKNIESIVC QGASPDLTFF LEISPEESIF
160 170 180 190 200
RRKNEIPDRI ESEGIRFLER VNEGFKLIAK QKNWKVISAS QNIKTISNQI
210
KETLLNNFSN AK
Length:212
Mass (Da):23,933
Last modified:April 3, 2007 - v1
Checksum:i4E0DDAB49A08D261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA Translation: ABO16772.1
RefSeqiWP_011862175.1, NC_009091.1

Genome annotation databases

EnsemblBacteriaiABO16772; ABO16772; P9301_01491
GeneIDi4912788
KEGGipmg:P9301_01491

Similar proteinsi

Entry informationi

Entry nameiKTHY_PROM0
AccessioniPrimary (citable) accession number: A3PAJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health