A3PAC7 (A3PAC7_PROM0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide deformylase HAMAP MF_00163
Short name=PDF HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163

Alternative name(s):
Polypeptide deformylase HAMAP MF_00163

Gene names

Name:	def HAMAP MF_00163
Ordered Locus Names:	P9301_00791

Organism

Prochlorococcus marinus (strain MIT 9301) [Complete proteome] [HAMAP] EMBL ABO16702.1

Taxonomic identifier

167546 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163
Catalytic activity	Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163 SAAS SAAS000181
Cofactor	Binds 1 Fe2+ ion By similarity. HAMAP MF_00163
Sequence similarities	Belongs to the polypeptide deformylase family. HAMAP MF_00163

Ontologies

Keywords
Biological process	Protein biosynthesis HAMAP MF_00163 SAAS SAAS000181
Ligand	Iron HAMAP MF_00163 Metal-binding HAMAP MF_00163 SAAS SAAS000181
Molecular function	Hydrolase HAMAP MF_00163 SAAS SAAS000181 EMBL ABO16702.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro peptide deformylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	164	1	By similarity HAMAP MF_00163
	Metal binding	121	1	Iron By similarity HAMAP MF_00163
	Metal binding	163	1	Iron By similarity HAMAP MF_00163
	Metal binding	167	1	Iron By similarity HAMAP MF_00163

Sequences

	Sequence		Length	Mass (Da)
	A3PAC7 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 08C71EB6CB1B7625	FASTA	201	22,512
	10 20 30 40 50 60 MANHFSQLAK KSRTNGNAEK IAKEQPGKPS LDIYKLGDDV LRQNSKRITK VDESIRKLAR 70 80 90 100 110 120 EMLQSMYAAK GIGLAAPQIG INKELLVIDV NFEDSAAEPL ILINPEITDF GTTLNSYEEG 130 140 150 160 170 180 CLSIPGVYLN VVRPSTIKLK FRDEMGRPRK MKADGLLARC IQHEMDHLNG ILFVDRVTSK 190 200 DDLNKELLKE GFNEKDVISI N

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000576 Genomic DNA. Translation: ABO16702.1.
RefSeq	YP_001090303.1. NC_009091.1.
3D structure databases
ProteinModelPortal	A3PAC7.
ModBase	Search...
Protein-protein interaction databases
STRING	A3PAC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4911246.
GenomeReviews	Gene locus P9301_00791 in contig CP000576_GR.
KEGG	pmg:P9301_00791.
PATRIC	22993747. VBIProMar103344_0078.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0242.
HOGENOM	HBG665227.
OMA	RITKVDE.
PhylomeDB	A3PAC7.
ProtClustDB	PRK00150.
Enzyme and pathway databases
BioCyc	PMAR167546:P9301ORF_0082-MONOMER.
Family and domain databases
HAMAP	MF_00163. Pep_deformylase. [Tree]
InterPro	IPR000181. Fmet_deformylase. IPR023635. Peptide_deformylase. [Graphical view]
Gene3D	G3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KO	K01462.
PANTHER	PTHR10458. Fmet_deformylase. 1 hit.
Pfam	PF01327. Pep_deformylase. 1 hit. [Graphical view]
PIRSF	PIRSF004749. Pep_def. 1 hit.
PRINTS	PR01576. PDEFORMYLASE.
SUPFAM	SSF56420. Fmet_deformylase. 1 hit.
TIGRFAMs	TIGR00079. Pept_deformyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3PAC7_PROM0

Accession

Primary (citable) accession number: A3PAC7

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)