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Protein

Protein GrpE

Gene

grpE

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

BioCyciPMAR167546:G1G8B-17-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:P9301_00151
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000536131 – 239Protein GrpEAdd BLAST239

Proteomic databases

PRIDEiA3PA63.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi167546.P9301_00151.

Structurei

3D structure databases

ProteinModelPortaliA3PA63.
SMRiA3PA63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107Z9D. Bacteria.
COG0576. LUCA.
HOGENOMiHOG000252083.
KOiK03687.
OMAiYAYEKIA.
OrthoDBiPOG091H00J8.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiView protein in InterPro
IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiView protein in Pfam
PF01025. GrpE. 1 hit.
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
SSF58014. SSF58014. 1 hit.

Sequencei

Sequence statusi: Complete.

A3PA63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIENQSDNID NKEIDVSIQD NAPEDKSSMQ NSTTENDELS SQKTEEINTE
60 70 80 90 100
ELKNTISNND ARLEQLEKEH ETLKNQYVRI SADFDNFRKR QSRDQDDLKI
110 120 130 140 150
QLVSKTLTAI LPIVDNFERA RQQLKPESEE AQALHRSYQG LYKQLVEVLK
160 170 180 190 200
QQGVSPMRVV GQQFDPNLHE AVLREPSEEF EEDFIIEELQ RGYHLEGKVL
210 220 230
RHALAKVSMG PGKQKSQQEV EKDTVEGDVD SDANTSEDV
Length:239
Mass (Da):27,443
Last modified:April 3, 2007 - v1
Checksum:iA469718BD8C5A576
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA. Translation: ABO16638.1.
RefSeqiWP_011862043.1. NC_009091.1.

Genome annotation databases

EnsemblBacteriaiABO16638; ABO16638; P9301_00151.
GeneIDi4912361.
KEGGipmg:P9301_00151.

Similar proteinsi

Entry informationi

Entry nameiGRPE_PROM0
AccessioniPrimary (citable) accession number: A3PA63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome