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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciBPSE357348:G1G89-6750-MONOMER
UniPathwayiUPA00578; UER00638

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:BURPS1106A_A2662
OrganismiBurkholderia pseudomallei (strain 1106a)
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000006738 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000696571 – 440Thymidine phosphorylaseAdd BLAST440

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA3P8N2
SMRiA3P8N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000047313
KOiK00758
OMAiVHSIGGV

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_01628 Thymid_phosp, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
IPR013465 Thymidine_Pase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02643 T_phosphoryl, 1 hit
TIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A3P8N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFLPQEFIR KVRDRAPLDT ADVARFVQGV TAGDVTEGQI AAFAMAVYFN
60 70 80 90 100
ELPLSARIAL TLAQRDSGDV LDWRGARLNG PVVDKHSTGG VGDLTSLVIG
110 120 130 140 150
PMVAACGGYV PMISGRGLGH TGGTLDKLEA IPGYDVAPSV DMLRRVVRDA
160 170 180 190 200
GLAIVGQTAQ LAPADKRIYA VRDVTATVES ISLITASILS KKLAAGVSAL
210 220 230 240 250
AMDVKVGSGA FMPSAEQSAE LARSIVDVGN GAGMRTAATL TDMNQALAPC
260 270 280 290 300
AGNAIEVRCA IDFLTGAARP ARLEAVSFAL AAQMLTMGGL AADAHDARRR
310 320 330 340 350
LRAVLESGAA AERFARMVAA LGGPADLVER PERHLPRAAA AAPVAAARAG
360 370 380 390 400
WIERIDARAL GLAVVGLGGG RAKIGDTLDY SVGLSALAEL GERVEAGQPL
410 420 430 440
ATVHARDADS AAQATDAVRR AYRIGAEPPA QTRVVHAVIE
Length:440
Mass (Da):45,433
Last modified:April 3, 2007 - v1
Checksum:i8DC26B70D8985899
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000573 Genomic DNA Translation: ABN92660.1
RefSeqiWP_004537472.1, NC_009078.1

Genome annotation databases

EnsemblBacteriaiABN92660; ABN92660; BURPS1106A_A2662
KEGGibpl:BURPS1106A_A2662

Similar proteinsi

Entry informationi

Entry nameiTYPH_BURP0
AccessioniPrimary (citable) accession number: A3P8N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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