Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A3P8N2 (TYPH_BURP0) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:BURPS1106A_A2662
OrganismBurkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]
Taxonomic identifier357348 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000069657

Sequences

Sequence LengthMass (Da)Tools
A3P8N2 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 8DC26B70D8985899

FASTA44045,433
        10         20         30         40         50         60 
MTFLPQEFIR KVRDRAPLDT ADVARFVQGV TAGDVTEGQI AAFAMAVYFN ELPLSARIAL 

        70         80         90        100        110        120 
TLAQRDSGDV LDWRGARLNG PVVDKHSTGG VGDLTSLVIG PMVAACGGYV PMISGRGLGH 

       130        140        150        160        170        180 
TGGTLDKLEA IPGYDVAPSV DMLRRVVRDA GLAIVGQTAQ LAPADKRIYA VRDVTATVES 

       190        200        210        220        230        240 
ISLITASILS KKLAAGVSAL AMDVKVGSGA FMPSAEQSAE LARSIVDVGN GAGMRTAATL 

       250        260        270        280        290        300 
TDMNQALAPC AGNAIEVRCA IDFLTGAARP ARLEAVSFAL AAQMLTMGGL AADAHDARRR 

       310        320        330        340        350        360 
LRAVLESGAA AERFARMVAA LGGPADLVER PERHLPRAAA AAPVAAARAG WIERIDARAL 

       370        380        390        400        410        420 
GLAVVGLGGG RAKIGDTLDY SVGLSALAEL GERVEAGQPL ATVHARDADS AAQATDAVRR 

       430        440 
AYRIGAEPPA QTRVVHAVIE 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1106a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000573 Genomic DNA. Translation: ABN92660.1.
RefSeqYP_001076692.1. NC_009078.1.

3D structure databases

ProteinModelPortalA3P8N2.
SMRA3P8N2. Positions 3-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357348.BURPS1106A_A2662.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN92660; ABN92660; BURPS1106A_A2662.
GeneID4904913.
KEGGbpl:BURPS1106A_A2662.
PATRIC19231231. VBIBurPse14980_6228.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMACGLAVPM.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycBPSE357348:GHVF-6744-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_BURP0
AccessionPrimary (citable) accession number: A3P8N2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways