A3P8L5 (ATPA2_BURP0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit alpha 2
EC=3.6.3.14

Alternative name(s):
ATP synthase F1 sector subunit alpha 2
F-ATPase subunit alpha 2

Gene names

Name:	atpA2
Ordered Locus Names:	BURPS1106A_A2645

Organism

Burkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]

Taxonomic identifier

357348 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	666 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP MF_01346
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01346.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 666	666	ATP synthase subunit alpha 2 HAMAP MF_01346		PRO_0000339024
Regions
	Nucleotide binding	182 – 189	8	ATP By similarity
Sites
	Site	375	1	Required for activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3P8L5 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 99FFF45310CB1B79	FASTA	666	69,832
	10 20 30 40 50 60 MTPTPDAPAA ADADAATGAG WLARRRGALA RVALAPVAQA IGRVERVADG IAFVSGLEDT 70 80 90 100 110 120 MLNEVLRFEG GVTGFAHTLD EDLISVVLLD PDAGVRAQTA VARTGAVLEV PAGPQLLGRV 130 140 150 160 170 180 VDPLGRPLDG GAPLDAAHTL PIERAAPAII ERDLVSEPLD TGVLIVDALF TIGRGQRELI 190 200 210 220 230 240 IGDRATGKTS LAIDAIVNQR HSDVICVYVA IGQRASAVRR VIDAVRRYGA PERCVFVVAP 250 260 270 280 290 300 AACAPGLQWI APFAGFSIAE YFRDRGQHAL VVVDDLTKHA ATHRELALLT REPPGREAYP 310 320 330 340 350 360 GDIFYVHARL LERAAKLSAA LGGGSLSALP IAETDAGNLA AYIPTNLISI TDGQIVLDSA 370 380 390 400 410 420 LFAANQRPAV DVGLSVSRVG GKAQHPALRA ASGRLRLDYA QFLELEAFTR FGGLTDARLR 430 440 450 460 470 480 AQITRGERIR ALITQPRFRA LRTLDEVVLL KALAAGALDA MSPDLVAPLR ERLPAWLDAR 490 500 510 520 530 540 IAALTPALAP PRDWLADDAA LDALAESVGE LIERIAADAA RRATAGMPAE DAAGDIGGAF 550 560 570 580 590 600 GGEQARGDAD RDADHGANRE VSREVSPEAS REVSREVSCE VSHEADRDAA ADAARVAGRA 610 620 630 640 650 660 PGRAEPDRAA PRAMPDGPPR AQADGDRASA SRPRPDARGD AARTAPSPQG GADANVDAEA EARHKR

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1106a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000573 Genomic DNA. Translation: ABN93049.1.
RefSeq	YP_001076675.1. NC_009078.1.
3D structure databases
ProteinModelPortal	A3P8L5.
SMR	A3P8L5. Positions 39-478.
ModBase	Search...
Protein-protein interaction databases
STRING	A3P8L5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4903302.
GenomeReviews	Gene locus BURPS1106A_A2645 in contig CP000573_GR.
KEGG	bpl:BURPS1106A_A2645.
PATRIC	19231199. VBIBurPse14980_6212.
TIGR	BURPS1106A_A2645.
Phylogenomic databases
eggNOG	COG0056.
HOGENOM	HBG565875.
OMA	NVLCVYC.
ProtClustDB	PRK13343.
Family and domain databases
HAMAP	MF_01346. ATP_synth_alpha_bact. [Tree]
InterPro	IPR020003. ATPase_a/bsu_AS. IPR005294. ATPase_F1-cplx_asu. IPR018118. ATPase_F1/A1-cplx_a/bsu_N. IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. [Graphical view]
Gene3D	G3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KO	K02111.
PANTHER	PTHR15184:SF3. ATPase_F1_a. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SUPFAM	SSF47917. ATPase_a/b_C. 1 hit. SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMs	TIGR00962. AtpA. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATPA2_BURP0

Accession

Primary (citable) accession number: A3P8L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program