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A3P826 (ACDH_BURP0) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:BURPS1106A_A2455
OrganismBurkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]
Taxonomic identifier357348 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387635

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding162 – 1709NAD By similarity

Sites

Active site1301Acyl-thioester intermediate By similarity
Binding site2721NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A3P826 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 257A95CEF258323B

FASTA29732,288
        10         20         30         40         50         60 
MKSKSSRTRV AILGSGSIGL DLMFKVKASE QFDLKFVVGR NANSDGLRLA RSCNVETSSD 

        70         80         90        100        110        120 
GLDFLKAHED AYDLVFDATS AAAHKVNNRF FSDAGKFVID LTPAKVGRLC VPCINLDDMG 

       130        140        150        160        170        180 
AEQNVNLITC GGQASLPLAY ALKQAVDEID YLEVVSAIAS RSAGIATREN IDEYMTTTEY 

       190        200        210        220        230        240 
ALAKFSGAKK TKAILNINPA EPGVRMQTTL YAYARYRDFD RVRASVADMV EKVREYVPGY 

       250        260        270        280        290 
RLVVEPLESQ GRITIGLTVR GRGDYLPEYA GNLDIINCAA LAVASHRHAT ARLGATQ 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1106a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000573 Genomic DNA. Translation: ABN95095.1.
RefSeqYP_001076486.1. NC_009078.1.

3D structure databases

ProteinModelPortalA3P826.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357348.BURPS1106A_A2455.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN95095; ABN95095; BURPS1106A_A2455.
GeneID4904369.
KEGGbpl:BURPS1106A_A2455.
PATRIC19230840. VBIBurPse14980_6034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHQGNVNM.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycBPSE357348:GHVF-6537-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_BURP0
AccessionPrimary (citable) accession number: A3P826
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families