A3P7Z0 (KHSE_BURP0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BURPS1106A_A2419

Organism

Burkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]

Taxonomic identifier

357348 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Homoserine kinase HAMAP MF_00301		PRO_0000300788

Sequences

	Sequence		Length	Mass (Da)
	A3P7Z0 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 58716C289DEA937C	FASTA	331	36,760
	10 20 30 40 50 60 MAVFTAVSDA DLALWMRHYD LGDVVAFRGI PSGIENSNFF LTTTRGEYVL TIFENLTAGQ 70 80 90 100 110 120 LPFYVDLMSH LAKHGVPVPA PVARDDGTLF GELHGKPAAI VTKLEGAAQL APGVEHCVEV 130 140 150 160 170 180 GQMLARMHLA GRDYPRHQPN LRSLPWWRDT VPAIAPFVTG EQRALLEGEL AHQAAFFASD 190 200 210 220 230 240 DYAALPEGPC HCDLFRDNAL FAHAEPDTGH SVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLPTGALDA ARADALLRAY QTVRPFTAGE RRHWGDMLRA GAYRFWVSRL YDFHLPRAAQ 310 320 330 MLKPHDPGHF ERILRERIAH AGALPETHAC N

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1106a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000573 Genomic DNA. Translation: ABN92955.1.
RefSeq	YP_001076450.1. NC_009078.1.
3D structure databases
ProteinModelPortal	A3P7Z0.
ModBase	Search...
Protein-protein interaction databases
STRING	A3P7Z0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4903721.
GenomeReviews	Gene locus BURPS1106A_A2419 in contig CP000573_GR.
KEGG	bpl:BURPS1106A_A2419.
PATRIC	19230772. VBIBurPse14980_6000.
TIGR	BURPS1106A_A2419.
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURP0

Accession

Primary (citable) accession number: A3P7Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program