A3P6B1 (A3P6B1_BURP0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Choline dehydrogenase HAMAP MF_00750
Short name=CDH HAMAP MF_00750
Short name=CHD HAMAP MF_00750
EC=1.1.99.1 HAMAP MF_00750

Gene names

Name:	betA HAMAP MF_00750
Ordered Locus Names:	BURPS1106A_A1837

Organism

Burkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP] EMBL ABN95040.1

Taxonomic identifier

357348 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750 SAAS SAAS007867
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750 SAAS SAAS007867
Cofactor	FAD By similarity. HAMAP MF_00750 SAAS SAAS007867
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750 SAAS SAAS007867
Sequence similarities	Belongs to the GMC oxidoreductase family. HAMAP MF_00750

Ontologies

Keywords
Ligand	FAD HAMAP MF_00750 SAAS SAAS011533 Flavoprotein HAMAP MF_00750 SAAS SAAS011533
Molecular function	Oxidoreductase HAMAP MF_00750 SAAS SAAS007867 EMBL ABN95040.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	7 – 36	30	FAD By similarity HAMAP MF_00750
Sites
	Active site	474	1	By similarity HAMAP MF_00750

Sequences

	Sequence		Length	Mass (Da)
	A3P6B1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 5C8B83535E7AB47B	FASTA	565	62,689
	10 20 30 40 50 60 MTTREFDYII CGAGSAGNVL ATRLTEDPGV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG 70 80 90 100 110 120 RRYNWAYETD PEPHMNHRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW ATHKGLEDWA 130 140 150 160 170 180 YLDCLPYFRK AETRDVGPND YHGGDGPVSV TTSKPGVNPL FEAMVEAGVQ AGYPRTDDLN 190 200 210 220 230 240 GYQQEGFGPM DRTVTPRGRR ASTARGYLDQ ARARPNLEIV THALADRILF SGKRATGVTF 250 260 270 280 290 300 LHGSARVTAH ARREVLVCSG AIASPQLLQR SGVGPGEWLR ELDIPVVLDL PGVGRNLQDH 310 320 330 340 350 360 LEMYIQFECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDPWPN 370 380 390 400 410 420 IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL KSRDPHAHPS ILFNYMAEAL 430 440 450 460 470 480 DWREFRDAIR ATREIMRQPA LDRFRGRELN PGADLKSDNE LDTFVRARAE TAFHPSCSCK 490 500 510 520 530 540 MGYDDMAVVD NEGRVHGIDG LRVVDASIMP IITTGNLNAP TIMIAEKIAD RIRQHKPLER 550 560 SNAQYYVANG APARGGKPAR APAVV

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000573 Genomic DNA. Translation: ABN95040.1.
RefSeq	YP_001075871.1. NC_009078.1.
3D structure databases
ProteinModelPortal	A3P6B1.
ModBase	Search...
Protein-protein interaction databases
STRING	A3P6B1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4903949.
GenomeReviews	Gene locus BURPS1106A_A1837 in contig CP000573_GR.
KEGG	bpl:BURPS1106A_A1837.
PATRIC	19229705. VBIBurPse14980_5469.
TIGR	BURPS1106A_A1837.
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	RSTAPYY.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A3P6B1_BURP0

Accession

Primary (citable) accession number: A3P6B1

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)